FGF23 production by osteocytes

Lynda F. Bonewald, Michael J. Wacker

Research output: Contribution to journalReview article

52 Scopus citations

Abstract

Fibroblast Growth Factor 23 (FGF23), a known regulator of phosphate homeostasis, is produced by cells residing in bone, namely, osteocytes, to target a distant organ, the kidney. Elevated FGF23 levels have recently been found systemically and in osteocytes in patients and animal models of chronic kidney disease. Associations between serum FGF23 level and vascular dysfunction, vascular calcification, and increased risk of cardiovascular disease have also been observed. In this review we discuss FGF23 expression in osteocytes and the potential means to regulate expression and function of this protein at the osteocyte level.

Original languageEnglish (US)
Pages (from-to)563-568
Number of pages6
JournalPediatric Nephrology
Volume28
Issue number4
DOIs
StatePublished - Apr 1 2013

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Keywords

  • Bone metabolism
  • Cardiovascular disease
  • Fibroblast growth factor 23
  • Osteocytes
  • Phosphate homeostasis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Nephrology

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