FGF23 production by osteocytes

Lynda Bonewald, Michael J. Wacker

Research output: Contribution to journalReview article

47 Citations (Scopus)

Abstract

Fibroblast Growth Factor 23 (FGF23), a known regulator of phosphate homeostasis, is produced by cells residing in bone, namely, osteocytes, to target a distant organ, the kidney. Elevated FGF23 levels have recently been found systemically and in osteocytes in patients and animal models of chronic kidney disease. Associations between serum FGF23 level and vascular dysfunction, vascular calcification, and increased risk of cardiovascular disease have also been observed. In this review we discuss FGF23 expression in osteocytes and the potential means to regulate expression and function of this protein at the osteocyte level.

Original languageEnglish (US)
Pages (from-to)563-568
Number of pages6
JournalPediatric Nephrology
Volume28
Issue number4
DOIs
StatePublished - Apr 2013
Externally publishedYes

Fingerprint

Osteocytes
Vascular Calcification
Chronic Renal Insufficiency
Blood Vessels
Homeostasis
Cardiovascular Diseases
Animal Models
Phosphates
Kidney
Bone and Bones
fibroblast growth factor 23
Serum
Proteins

Keywords

  • Bone metabolism
  • Cardiovascular disease
  • Fibroblast growth factor 23
  • Osteocytes
  • Phosphate homeostasis

ASJC Scopus subject areas

  • Nephrology
  • Pediatrics, Perinatology, and Child Health
  • Medicine(all)

Cite this

FGF23 production by osteocytes. / Bonewald, Lynda; Wacker, Michael J.

In: Pediatric Nephrology, Vol. 28, No. 4, 04.2013, p. 563-568.

Research output: Contribution to journalReview article

Bonewald, Lynda ; Wacker, Michael J. / FGF23 production by osteocytes. In: Pediatric Nephrology. 2013 ; Vol. 28, No. 4. pp. 563-568.
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