Fibrillary glomerulonephritis related to serum fibrillar immunoglobulin- fibronectin complexes

Agueda Rostagno, Ruben Vidal, Asok Kumar, Joseph Chuba, George Niederman, Leslie Gold, Blas Frangione, Jorge Ghiso, Gloria Gallo

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

Fibrillary glomerulonephritis is a disease of uncertain origin and pathogenesis characterized by nonamyloidotic fibrils in glomeruli. We report immunohistological, immunochemical, and biochemical studies of a serum fibrillar cryoprecipitate obtained from a patient with fibrillary glomerulonephritis, that formed on prolonged storage at 4°C. By Western blot and amino acid sequence analysis, the cryoprecipitated fibril components consisted of immunoglobulins, heavy chains γ, and μ, light chains κ and λ, and fibronectin, similar to the proteins identified by immunofluorescence and immunoelectron microscopy in the glomerular fibrils. These findings support the hypothesis that serum precursors may be the source of the fibrillar deposits and suggest a role for immunoglobulin-fibronectin complexes in the pathogenesis of fibrillary glomerulonephritis.

Original languageEnglish (US)
Pages (from-to)676-684
Number of pages9
JournalAmerican Journal of Kidney Diseases
Volume28
Issue number5
DOIs
StatePublished - Nov 1996
Externally publishedYes

Keywords

  • Fibrillary GN
  • cryoprotein
  • fibronectin
  • immune complexes

ASJC Scopus subject areas

  • Nephrology

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    Rostagno, A., Vidal, R., Kumar, A., Chuba, J., Niederman, G., Gold, L., Frangione, B., Ghiso, J., & Gallo, G. (1996). Fibrillary glomerulonephritis related to serum fibrillar immunoglobulin- fibronectin complexes. American Journal of Kidney Diseases, 28(5), 676-684. https://doi.org/10.1016/S0272-6386(96)90248-6