Fibrinogen may mediate the association between long sleep duration and coronary heart disease

Lauren Hale, Victoria Parente, Jennifer Beam Dowd, Megan Sands, Jeffrey S. Berger, Yiqing Song, Lisa W. Martin, Matthew A. Allison

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Long sleep duration has been associated with increased risk of cardiovascular disease (CVD) and all-cause mortality. Inflammation and coagulation have been hypothesized as possible physiological pathways to explain this association, although specific biomarkers have not been studied. Using longitudinal data from 3942 postmenopausal women in the Women's Health Initiative observational study and clinical trials, we investigated whether fibrinogen, an acute-phase inflammatory protein involved in blood clotting, mediates the associations between sleep duration and coronary heart disease (CHD) and mortality among women. Fibrinogen levels were associated positively with self-reported long sleep duration (9+ h per night), CHD and all-cause mortality, even after adjustment for a range of sociodemographic characteristics, cardiovascular risk factors and comorbidities.Compared with self-reported 7-8 h per night sleep duration, self-reported long sleep duration was associated with increased odds of CHD [odds ratio (OR) = 2.05, 95% confidence interval (CI): 1.02-4.11]. Adjustment for fibrinogen levels reduced the increased odds of CHD associated with long sleep by approximately 8 percentage points (OR = 1.97, 95% CI: 0.98-3.97). A similar reduction in the OR was observed with mortality. For both outcomes there is support for partial mediation of 6-7%, suggesting that fibrinogen may be a mechanism through which long sleep duration is associated with CHD and mortality.

Original languageEnglish (US)
Pages (from-to)305-314
Number of pages10
JournalJournal of Sleep Research
Volume22
Issue number3
DOIs
StatePublished - Jun 1 2013
Externally publishedYes

Fingerprint

Fibrinogen
Coronary Disease
Sleep
Mortality
Odds Ratio
Confidence Intervals
Acute-Phase Proteins
Blood Coagulation
Women's Health
Observational Studies
Comorbidity
Cardiovascular Diseases
Biomarkers
Clinical Trials
Inflammation

Keywords

  • Coagulation
  • Coronary heart disease
  • Fibrinogen
  • Long sleep
  • Mortality
  • Sleep duration

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Behavioral Neuroscience

Cite this

Hale, L., Parente, V., Dowd, J. B., Sands, M., Berger, J. S., Song, Y., ... Allison, M. A. (2013). Fibrinogen may mediate the association between long sleep duration and coronary heart disease. Journal of Sleep Research, 22(3), 305-314. https://doi.org/10.1111/jsr.12020

Fibrinogen may mediate the association between long sleep duration and coronary heart disease. / Hale, Lauren; Parente, Victoria; Dowd, Jennifer Beam; Sands, Megan; Berger, Jeffrey S.; Song, Yiqing; Martin, Lisa W.; Allison, Matthew A.

In: Journal of Sleep Research, Vol. 22, No. 3, 01.06.2013, p. 305-314.

Research output: Contribution to journalArticle

Hale, L, Parente, V, Dowd, JB, Sands, M, Berger, JS, Song, Y, Martin, LW & Allison, MA 2013, 'Fibrinogen may mediate the association between long sleep duration and coronary heart disease', Journal of Sleep Research, vol. 22, no. 3, pp. 305-314. https://doi.org/10.1111/jsr.12020
Hale, Lauren ; Parente, Victoria ; Dowd, Jennifer Beam ; Sands, Megan ; Berger, Jeffrey S. ; Song, Yiqing ; Martin, Lisa W. ; Allison, Matthew A. / Fibrinogen may mediate the association between long sleep duration and coronary heart disease. In: Journal of Sleep Research. 2013 ; Vol. 22, No. 3. pp. 305-314.
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