Fibroblast Growth Factor Receptors and Cancer-Associated Perturbations

M. Kornmann, Murray Korc

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Fibroblast growth factors (FGFs) are heparin-binding polypeptides involved in many important developmental processes including tissue patterning. FGFs act by binding to specific FGF receptors (FGFRs) that possess an intracellular kinase domain. In adult tissues, FGFs are involved in metabolic regulation, tissue repair, angiogenesis, and mitogenesis. Perturbations in FGF-FGFR expression, localization, and signaling have been implicated in several pathological processes, including malignant transformation, tumor spread, and metastasis. After a brief summary about FGFs and FGFRs and their physiologic actions, this article gives an overview about the involvement of FGFs and FGFRs in malignant diseases.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Biological Chemistry
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Pages303-308
Number of pages6
ISBN (Electronic)9780123786319
ISBN (Print)9780123786302
DOIs
StatePublished - Feb 15 2013
Externally publishedYes

Keywords

  • Angiogenesis
  • Cancer
  • Cancer stroma
  • Epithelial-mesenchymal transition
  • Fibroblast growth factor (FGF)
  • Fibroblast growth factor receptor (FGFR)
  • Heparin
  • Malignant transformation
  • Metastasis
  • Mitogenesis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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