Fibronectin turnover in the premature neonate measured with [15N]glycine

R. A. Polin, Mervin Yoder, S. D. Douglas, W. McNelis, I. Nissim, M. Yodkoff

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Fibronectin is a large-molecular-weight glycoprotein present on most cell surfaces and in plasma. Plasma fibronectin concentrations in neonates are lower than those in adults and a direct relationship exists between plasma concentration and gestational age. We determined the half-life and fractional synthetic rate (FSR) of plasma fibronectin in the premature infant. Infants and adults received a loading dose of [15N]glycine followed by a constant infusion. [15N]glycine incorporation into plasma fibronectin and urine hippurate was determined by gas chromatography-mass spectrometry. The plama fibronectin FSR in the preterm neonates was 15.5 ± 9.9%/d (x̄ ± SD) and the half-life was 5.55 ± 2.25 d. Birth weight correlated inversely with plasma fibronectin half-life. In the adults the plasma fibronectin FSR ranged from 20 to 87%/d and half-life ranged between 0.79 and 3.47 d. These data suggest that decreased plasma fibronectin levels in preterm infants are due to reduced FSRs rather than to greater turnover of a relatively small plasma pool.

Original languageEnglish (US)
Pages (from-to)314-319
Number of pages6
JournalAmerican Journal of Clinical Nutrition
Volume49
Issue number2
StatePublished - 1989
Externally publishedYes

Fingerprint

fibronectins
Fibronectins
Glycine
neonates
Newborn Infant
half life
Half-Life
Premature Infants
gestational age
birth weight
Birth Weight
glycoproteins
Gas Chromatography-Mass Spectrometry
Gestational Age
urine
Glycoproteins
molecular weight
Molecular Weight
Urine
dosage

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)

Cite this

Polin, R. A., Yoder, M., Douglas, S. D., McNelis, W., Nissim, I., & Yodkoff, M. (1989). Fibronectin turnover in the premature neonate measured with [15N]glycine. American Journal of Clinical Nutrition, 49(2), 314-319.

Fibronectin turnover in the premature neonate measured with [15N]glycine. / Polin, R. A.; Yoder, Mervin; Douglas, S. D.; McNelis, W.; Nissim, I.; Yodkoff, M.

In: American Journal of Clinical Nutrition, Vol. 49, No. 2, 1989, p. 314-319.

Research output: Contribution to journalArticle

Polin, RA, Yoder, M, Douglas, SD, McNelis, W, Nissim, I & Yodkoff, M 1989, 'Fibronectin turnover in the premature neonate measured with [15N]glycine', American Journal of Clinical Nutrition, vol. 49, no. 2, pp. 314-319.
Polin, R. A. ; Yoder, Mervin ; Douglas, S. D. ; McNelis, W. ; Nissim, I. ; Yodkoff, M. / Fibronectin turnover in the premature neonate measured with [15N]glycine. In: American Journal of Clinical Nutrition. 1989 ; Vol. 49, No. 2. pp. 314-319.
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