Fibronectin turnover in the premature neonate measured with [15N]glycine

R. A. Polin, M. C. Yoder, S. D. Douglas, W. McNelis, I. Nissim, M. Yodkoff

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Fibronectin is a large-molecular-weight glycoprotein present on most cell surfaces and in plasma. Plasma fibronectin concentrations in neonates are lower than those in adults and a direct relationship exists between plasma concentration and gestational age. We determined the half-life and fractional synthetic rate (FSR) of plasma fibronectin in the premature infant. Infants and adults received a loading dose of [15N]glycine followed by a constant infusion. [15N]glycine incorporation into plasma fibronectin and urine hippurate was determined by gas chromatography-mass spectrometry. The plama fibronectin FSR in the preterm neonates was 15.5 ± 9.9%/d (x̄ ± SD) and the half-life was 5.55 ± 2.25 d. Birth weight correlated inversely with plasma fibronectin half-life. In the adults the plasma fibronectin FSR ranged from 20 to 87%/d and half-life ranged between 0.79 and 3.47 d. These data suggest that decreased plasma fibronectin levels in preterm infants are due to reduced FSRs rather than to greater turnover of a relatively small plasma pool.

Original languageEnglish (US)
Pages (from-to)314-319
Number of pages6
JournalAmerican Journal of Clinical Nutrition
Volume49
Issue number2
DOIs
StatePublished - 1989

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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