Finding genes for bipolar disorder in the functional genomics era

From convergent functional genomics to phenomics and back

Alexander Niculescu, John R. Kelsoe

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Psychiatric genetics, while promising to unravel the mechanisms of psychiatric disorders, has proven to be a challenging field. Psychiatric disorders, like other common genetic traits, are complex and heterogeneous. Psychiatric genetics has also suffered from a lack of quantifiable, biology-based phenotypes. However, the field is currently at an opportune moment. The work of various investigators is on the verge of paying rich dividends. Efforts at positional cloning are being greatly accelerated by the fruits of the Human Genome Project. New tools of functional genomics, such as expression profiling and proteomics, are being applied to animal models. These two methods can complement each other in an approach we have termed convergent functional genomics. Lastly, improvements in the measurement of biologically distinct endophenotypes-or phenomics-will lead to a better understanding of the mapping of genes to phenotypes in both animal and human systems.

Original languageEnglish (US)
Pages (from-to)215-226
Number of pages12
JournalCNS Spectrums
Volume7
Issue number3
StatePublished - 2002
Externally publishedYes

Fingerprint

Genomics
Bipolar Disorder
Psychiatry
Genes
Endophenotypes
Human Genome Project
Phenotype
Chromosome Mapping
Proteomics
Organism Cloning
Fruit
Animal Models
Research Personnel

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology

Cite this

Finding genes for bipolar disorder in the functional genomics era : From convergent functional genomics to phenomics and back. / Niculescu, Alexander; Kelsoe, John R.

In: CNS Spectrums, Vol. 7, No. 3, 2002, p. 215-226.

Research output: Contribution to journalArticle

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