Finding genes for bipolar disorder in the functional genomics era: From convergent functional genomics to phenomics and back

Alexander B. Niculescu, John R. Kelsoe

Research output: Contribution to journalReview article

18 Scopus citations

Abstract

Psychiatric genetics, while promising to unravel the mechanisms of psychiatric disorders, has proven to be a challenging field. Psychiatric disorders, like other common genetic traits, are complex and heterogeneous. Psychiatric genetics has also suffered from a lack of quantifiable, biology-based phenotypes. However, the field is currently at an opportune moment. The work of various investigators is on the verge of paying rich dividends. Efforts at positional cloning are being greatly accelerated by the fruits of the Human Genome Project. New tools of functional genomics, such as expression profiling and proteomics, are being applied to animal models. These two methods can complement each other in an approach we have termed convergent functional genomics. Lastly, improvements in the measurement of biologically distinct endophenotypes-or phenomics-will lead to a better understanding of the mapping of genes to phenotypes in both animal and human systems.

Original languageEnglish (US)
Pages (from-to)215-226
Number of pages12
JournalCNS Spectrums
Volume7
Issue number3
DOIs
StatePublished - Jan 1 2002
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

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