Fine-Needle Aspiration Cytology of Blastic Natural Killer-Cell Lymphoma (CD4+ CD56+ Hematodermic Neoplasm)

Howard Wu, Rulong Ren, Janet E. Roepke

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

We describe fine-needle aspiration (FNA) cytology findings of a case of blastic natural killer (NK)-cell lymphoma. The patient was a 68-year-old man who was diagnosed with cutaneous blastic NK-cell lymphoma involving his forehead. He developed a 1.5 cm, right pre-auricular lymph node five months later. FNA cytology revealed a monomorphic population of medium-sized lymphoid cells with a dispersed single cell arrangement. The tumor cells contained eccentrically located nuclei with a plasmacytoloid appearance and moderate amount of grayish cytoplasm without azurophilic granules. The nuclei were round to oval with fine chromatin, small indistinct nucleoli, and frequent nuclear indentation. Many cells also showed elongated cytoplasm with a unique hand-mirror or ping-pong paddle-like appearance. The flow cytometry study obtained during the FNA revealed co-expression of CD4 and CD56 in the tumor cells that confirm the recurrence of a blastic NK-cell lymphoma to the pre-auricular lymph node.

Original languageEnglish (US)
Pages (from-to)268-270
Number of pages3
JournalDiagnostic Cytopathology
Volume30
Issue number4
DOIs
StatePublished - Apr 2004
Externally publishedYes

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Fine Needle Biopsy
Natural Killer Cells
Cell Biology
Lymphoma
Neoplasms
Cytoplasm
Lymph Nodes
Forehead
Chromatin
Flow Cytometry
Hand
Lymphocytes
Recurrence
Skin
Population

Keywords

  • Blastic natural-killer cell lymphoma
  • Fine-needle aspiration cytology

ASJC Scopus subject areas

  • Anatomy

Cite this

Fine-Needle Aspiration Cytology of Blastic Natural Killer-Cell Lymphoma (CD4+ CD56+ Hematodermic Neoplasm). / Wu, Howard; Ren, Rulong; Roepke, Janet E.

In: Diagnostic Cytopathology, Vol. 30, No. 4, 04.2004, p. 268-270.

Research output: Contribution to journalArticle

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