Fine-needle aspiration cytology of metastatic spindle cell follicular thyroid carcinoma: A case report

Yu Hsin Chen, Carmen M. Perrino, Liang Cheng, Howard Wu

Research output: Contribution to journalArticle

Abstract

Follicular thyroid carcinoma, spindle cell variant is extremely rare. The tumor is predominantly composed of spindle cells with a fusiform appearance that are arranged in intersecting fascicles. Fine-needle aspiration biopsy of this entity has not been previously described. We report a case of a 58-year-old woman who presented with metastasis to a left neck lymph node 15 years after the original diagnosis. Fine-needle aspiration cytology showed numerous bland, spindled to epithelioid cells with thin, elongated, and plump nuclei with finely granular chromatin and inconspicuous nucleoli. The tumor cells had a moderate amount of cytoplasm with occasional elongated cytoplasmic tails. The cells were arranged in irregular aggregates with a fascicular pattern or singly dispersed. The tumor cells demonstrated positive staining for pan-keratin, PAX8, thyroid transcription factor-1, and thyroglobulin, which confirmed thyroid primary origin.

Original languageEnglish (US)
JournalDiagnostic Cytopathology
DOIs
StatePublished - Jan 1 2019

Fingerprint

Follicular Adenocarcinoma
Fine Needle Biopsy
Cell Biology
Epithelioid Cells
Neoplasms
Thyroglobulin
Keratins
Chromatin
Thyroid Gland
Cytoplasm
Neck
Lymph Nodes
Staining and Labeling
Neoplasm Metastasis

Keywords

  • cytology
  • fine-needle aspiration
  • spindle cell
  • thyroid follicular carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

Cite this

Fine-needle aspiration cytology of metastatic spindle cell follicular thyroid carcinoma : A case report. / Chen, Yu Hsin; Perrino, Carmen M.; Cheng, Liang; Wu, Howard.

In: Diagnostic Cytopathology, 01.01.2019.

Research output: Contribution to journalArticle

@article{8816768182d841a29e100457699e81f8,
title = "Fine-needle aspiration cytology of metastatic spindle cell follicular thyroid carcinoma: A case report",
abstract = "Follicular thyroid carcinoma, spindle cell variant is extremely rare. The tumor is predominantly composed of spindle cells with a fusiform appearance that are arranged in intersecting fascicles. Fine-needle aspiration biopsy of this entity has not been previously described. We report a case of a 58-year-old woman who presented with metastasis to a left neck lymph node 15 years after the original diagnosis. Fine-needle aspiration cytology showed numerous bland, spindled to epithelioid cells with thin, elongated, and plump nuclei with finely granular chromatin and inconspicuous nucleoli. The tumor cells had a moderate amount of cytoplasm with occasional elongated cytoplasmic tails. The cells were arranged in irregular aggregates with a fascicular pattern or singly dispersed. The tumor cells demonstrated positive staining for pan-keratin, PAX8, thyroid transcription factor-1, and thyroglobulin, which confirmed thyroid primary origin.",
keywords = "cytology, fine-needle aspiration, spindle cell, thyroid follicular carcinoma",
author = "Chen, {Yu Hsin} and Perrino, {Carmen M.} and Liang Cheng and Howard Wu",
year = "2019",
month = "1",
day = "1",
doi = "10.1002/dc.24159",
language = "English (US)",
journal = "Diagnostic Cytopathology",
issn = "8755-1039",
publisher = "Wiley-Liss Inc.",

}

TY - JOUR

T1 - Fine-needle aspiration cytology of metastatic spindle cell follicular thyroid carcinoma

T2 - A case report

AU - Chen, Yu Hsin

AU - Perrino, Carmen M.

AU - Cheng, Liang

AU - Wu, Howard

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Follicular thyroid carcinoma, spindle cell variant is extremely rare. The tumor is predominantly composed of spindle cells with a fusiform appearance that are arranged in intersecting fascicles. Fine-needle aspiration biopsy of this entity has not been previously described. We report a case of a 58-year-old woman who presented with metastasis to a left neck lymph node 15 years after the original diagnosis. Fine-needle aspiration cytology showed numerous bland, spindled to epithelioid cells with thin, elongated, and plump nuclei with finely granular chromatin and inconspicuous nucleoli. The tumor cells had a moderate amount of cytoplasm with occasional elongated cytoplasmic tails. The cells were arranged in irregular aggregates with a fascicular pattern or singly dispersed. The tumor cells demonstrated positive staining for pan-keratin, PAX8, thyroid transcription factor-1, and thyroglobulin, which confirmed thyroid primary origin.

AB - Follicular thyroid carcinoma, spindle cell variant is extremely rare. The tumor is predominantly composed of spindle cells with a fusiform appearance that are arranged in intersecting fascicles. Fine-needle aspiration biopsy of this entity has not been previously described. We report a case of a 58-year-old woman who presented with metastasis to a left neck lymph node 15 years after the original diagnosis. Fine-needle aspiration cytology showed numerous bland, spindled to epithelioid cells with thin, elongated, and plump nuclei with finely granular chromatin and inconspicuous nucleoli. The tumor cells had a moderate amount of cytoplasm with occasional elongated cytoplasmic tails. The cells were arranged in irregular aggregates with a fascicular pattern or singly dispersed. The tumor cells demonstrated positive staining for pan-keratin, PAX8, thyroid transcription factor-1, and thyroglobulin, which confirmed thyroid primary origin.

KW - cytology

KW - fine-needle aspiration

KW - spindle cell

KW - thyroid follicular carcinoma

UR - http://www.scopus.com/inward/record.url?scp=85061976821&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85061976821&partnerID=8YFLogxK

U2 - 10.1002/dc.24159

DO - 10.1002/dc.24159

M3 - Article

C2 - 30794342

AN - SCOPUS:85061976821

JO - Diagnostic Cytopathology

JF - Diagnostic Cytopathology

SN - 8755-1039

ER -