Fine-needle aspiration cytology of metastatic spindle cell follicular thyroid carcinoma: A case report

Yu Hsin Chen, Carmen M. Perrino, Liang Cheng, Howard H. Wu

Research output: Contribution to journalArticle


Follicular thyroid carcinoma, spindle cell variant is extremely rare. The tumor is predominantly composed of spindle cells with a fusiform appearance that are arranged in intersecting fascicles. Fine-needle aspiration biopsy of this entity has not been previously described. We report a case of a 58-year-old woman who presented with metastasis to a left neck lymph node 15 years after the original diagnosis. Fine-needle aspiration cytology showed numerous bland, spindled to epithelioid cells with thin, elongated, and plump nuclei with finely granular chromatin and inconspicuous nucleoli. The tumor cells had a moderate amount of cytoplasm with occasional elongated cytoplasmic tails. The cells were arranged in irregular aggregates with a fascicular pattern or singly dispersed. The tumor cells demonstrated positive staining for pan-keratin, PAX8, thyroid transcription factor-1, and thyroglobulin, which confirmed thyroid primary origin.

Original languageEnglish (US)
Pages (from-to)608-611
Number of pages4
JournalDiagnostic Cytopathology
Issue number6
StatePublished - Jun 2019



  • cytology
  • fine-needle aspiration
  • spindle cell
  • thyroid follicular carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

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