Fine needle aspiration evaluation of pancreatic lymphoma

A retrospective study of 25 cases in a single institution

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1 Citation (Scopus)

Abstract

Background: Accurate diagnosis of pancreatic lymphoma is crucial for clinical management. We evaluate the role of fine-needle aspiration (FNA) in the diagnosis of pancreatic lymphoma with the aid of flow cytometry and/or immunohistochemistry on the cell block. Methods: Cases of pancreatic lymphoma were collected by searching our pathology laboratory information system over a period of 16 years. The clinical findings, cytologic features, and immunophenotypic results were reviewed. The diagnoses of FNA were correlated with surgical specimens in a subset of FNA cases. Results: A total of 25 FNA cases of pancreatic lymphoma were included. The most common type of pancreatic lymphoma was large B cell lymphoma followed by follicular lymphoma. With the aid of flow cytometry and immunohistochemical work-up on cell block, 72% (18/25) of the cases were diagnosed as lymphoma and 16% of the cases (4/25) were diagnosed as suspicious for lymphoma by FNA. Only two cases (8%) including one false negative and one nondiagnostic aspirate missed the lymphoma diagnosis and 1 case (4%) was indeterminate by FNA evaluation. Conclusion: FNA demonstrated high accuracy in rendering diagnosis of pancreatic lymphoma. The overall sensitivity is 88% and the false negative and nondiagnostic rates are 4%, respectively. Further subtyping of certain lymphomas can be difficult due to the lack of architectural features of FNA specimens.

Original languageEnglish (US)
JournalDiagnostic Cytopathology
DOIs
StateAccepted/In press - Jan 1 2017

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Fine Needle Biopsy
Lymphoma
Retrospective Studies
Flow Cytometry
Clinical Laboratory Information Systems
Follicular Lymphoma
B-Cell Lymphoma
Immunohistochemistry
Pathology

Keywords

  • Fine needle aspiration
  • Flow cytometry
  • Pancreatic lymphoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

Cite this

@article{953d9c591b304921ab584c7acd154990,
title = "Fine needle aspiration evaluation of pancreatic lymphoma: A retrospective study of 25 cases in a single institution",
abstract = "Background: Accurate diagnosis of pancreatic lymphoma is crucial for clinical management. We evaluate the role of fine-needle aspiration (FNA) in the diagnosis of pancreatic lymphoma with the aid of flow cytometry and/or immunohistochemistry on the cell block. Methods: Cases of pancreatic lymphoma were collected by searching our pathology laboratory information system over a period of 16 years. The clinical findings, cytologic features, and immunophenotypic results were reviewed. The diagnoses of FNA were correlated with surgical specimens in a subset of FNA cases. Results: A total of 25 FNA cases of pancreatic lymphoma were included. The most common type of pancreatic lymphoma was large B cell lymphoma followed by follicular lymphoma. With the aid of flow cytometry and immunohistochemical work-up on cell block, 72{\%} (18/25) of the cases were diagnosed as lymphoma and 16{\%} of the cases (4/25) were diagnosed as suspicious for lymphoma by FNA. Only two cases (8{\%}) including one false negative and one nondiagnostic aspirate missed the lymphoma diagnosis and 1 case (4{\%}) was indeterminate by FNA evaluation. Conclusion: FNA demonstrated high accuracy in rendering diagnosis of pancreatic lymphoma. The overall sensitivity is 88{\%} and the false negative and nondiagnostic rates are 4{\%}, respectively. Further subtyping of certain lymphomas can be difficult due to the lack of architectural features of FNA specimens.",
keywords = "Fine needle aspiration, Flow cytometry, Pancreatic lymphoma",
author = "Jiehao Zhou and Howard Wu and Jingmei Lin and Xiaoyan Wang and Shanxiang Zhang and Harvey Cramer and Shaoxiong Chen",
year = "2017",
month = "1",
day = "1",
doi = "10.1002/dc.23862",
language = "English (US)",
journal = "Diagnostic Cytopathology",
issn = "8755-1039",
publisher = "Wiley-Liss Inc.",

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T1 - Fine needle aspiration evaluation of pancreatic lymphoma

T2 - A retrospective study of 25 cases in a single institution

AU - Zhou, Jiehao

AU - Wu, Howard

AU - Lin, Jingmei

AU - Wang, Xiaoyan

AU - Zhang, Shanxiang

AU - Cramer, Harvey

AU - Chen, Shaoxiong

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Background: Accurate diagnosis of pancreatic lymphoma is crucial for clinical management. We evaluate the role of fine-needle aspiration (FNA) in the diagnosis of pancreatic lymphoma with the aid of flow cytometry and/or immunohistochemistry on the cell block. Methods: Cases of pancreatic lymphoma were collected by searching our pathology laboratory information system over a period of 16 years. The clinical findings, cytologic features, and immunophenotypic results were reviewed. The diagnoses of FNA were correlated with surgical specimens in a subset of FNA cases. Results: A total of 25 FNA cases of pancreatic lymphoma were included. The most common type of pancreatic lymphoma was large B cell lymphoma followed by follicular lymphoma. With the aid of flow cytometry and immunohistochemical work-up on cell block, 72% (18/25) of the cases were diagnosed as lymphoma and 16% of the cases (4/25) were diagnosed as suspicious for lymphoma by FNA. Only two cases (8%) including one false negative and one nondiagnostic aspirate missed the lymphoma diagnosis and 1 case (4%) was indeterminate by FNA evaluation. Conclusion: FNA demonstrated high accuracy in rendering diagnosis of pancreatic lymphoma. The overall sensitivity is 88% and the false negative and nondiagnostic rates are 4%, respectively. Further subtyping of certain lymphomas can be difficult due to the lack of architectural features of FNA specimens.

AB - Background: Accurate diagnosis of pancreatic lymphoma is crucial for clinical management. We evaluate the role of fine-needle aspiration (FNA) in the diagnosis of pancreatic lymphoma with the aid of flow cytometry and/or immunohistochemistry on the cell block. Methods: Cases of pancreatic lymphoma were collected by searching our pathology laboratory information system over a period of 16 years. The clinical findings, cytologic features, and immunophenotypic results were reviewed. The diagnoses of FNA were correlated with surgical specimens in a subset of FNA cases. Results: A total of 25 FNA cases of pancreatic lymphoma were included. The most common type of pancreatic lymphoma was large B cell lymphoma followed by follicular lymphoma. With the aid of flow cytometry and immunohistochemical work-up on cell block, 72% (18/25) of the cases were diagnosed as lymphoma and 16% of the cases (4/25) were diagnosed as suspicious for lymphoma by FNA. Only two cases (8%) including one false negative and one nondiagnostic aspirate missed the lymphoma diagnosis and 1 case (4%) was indeterminate by FNA evaluation. Conclusion: FNA demonstrated high accuracy in rendering diagnosis of pancreatic lymphoma. The overall sensitivity is 88% and the false negative and nondiagnostic rates are 4%, respectively. Further subtyping of certain lymphomas can be difficult due to the lack of architectural features of FNA specimens.

KW - Fine needle aspiration

KW - Flow cytometry

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