Fine needle aspiration of oncocytic variants of pancreatic neuroendocrine tumor

A report of three misdiagnosed cases

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objectives: An oncocytic variant of pancreatic neuroendocrine tumors (PanNET) is exceedingly rare. Here we report cytomorphological features of the oncocytic variant of PanNET and discuss how to avoid diagnostic pitfalls. Study Design: A computerized search of our laboratory information system was performed over an 18-year period to identify all cytology and surgical pathology cases where a diagnosis of PanNET was made or considered in the differential diagnosis. Three cases of the oncocytic variant of PanNET were identified. Results: Endoscopic ultrasound-guided fine needle aspiration (FNA) smears showed cohesive clusters of large atypical cells with abundant eosinophilic granular cytoplasm, anisonucleosis, nuclear enlargement and overlapping, prominent nucleoli, and a relatively smooth nuclear membrane. Nuclei were round to oval with finely granular chromatin. Additional features included rare isolated cells and glandular formation. Some of these morphological features, such as anisonucleosis, nuclear enlargement, and overlapping, prominent nucleoli, are also commonly seen in the pancreatic adenocarcinoma. All these cases were misclassified by FNA as adenocarcinoma (2 cases) or suspicious for carcinoma (1 case) and were histologically confirmed to be oncocytic variants of PanNET. Conclusions: Useful salient features of the oncocytic variant of PanNET include abundant eosinophilic granular cytoplasm, finely granular chromatin, and relatively smooth nuclear membrane. The awareness of this variant will help to avoid misdiagnosis.

Original languageEnglish
Pages (from-to)131-137
Number of pages7
JournalActa Cytologica
Volume58
Issue number2
DOIs
StatePublished - 2014

Fingerprint

Neuroendocrine Tumors
Fine Needle Biopsy
Diagnostic Errors
Nuclear Envelope
Chromatin
Cytoplasm
Adenocarcinoma
Clinical Laboratory Information Systems
Endoscopic Ultrasound-Guided Fine Needle Aspiration
Surgical Pathology
Cell Biology
Differential Diagnosis
Carcinoma

Keywords

  • Endoscopic ultrasound
  • Fine needle aspiration
  • Oncocytic variant of pancreatic neuroendocrine tumor

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

Cite this

Fine needle aspiration of oncocytic variants of pancreatic neuroendocrine tumor : A report of three misdiagnosed cases. / Chen, Shaoxiong; Wang, Xiaoyan; Lin, Jingmei.

In: Acta Cytologica, Vol. 58, No. 2, 2014, p. 131-137.

Research output: Contribution to journalArticle

@article{752b22be2dde4191964f20468b84fbab,
title = "Fine needle aspiration of oncocytic variants of pancreatic neuroendocrine tumor: A report of three misdiagnosed cases",
abstract = "Objectives: An oncocytic variant of pancreatic neuroendocrine tumors (PanNET) is exceedingly rare. Here we report cytomorphological features of the oncocytic variant of PanNET and discuss how to avoid diagnostic pitfalls. Study Design: A computerized search of our laboratory information system was performed over an 18-year period to identify all cytology and surgical pathology cases where a diagnosis of PanNET was made or considered in the differential diagnosis. Three cases of the oncocytic variant of PanNET were identified. Results: Endoscopic ultrasound-guided fine needle aspiration (FNA) smears showed cohesive clusters of large atypical cells with abundant eosinophilic granular cytoplasm, anisonucleosis, nuclear enlargement and overlapping, prominent nucleoli, and a relatively smooth nuclear membrane. Nuclei were round to oval with finely granular chromatin. Additional features included rare isolated cells and glandular formation. Some of these morphological features, such as anisonucleosis, nuclear enlargement, and overlapping, prominent nucleoli, are also commonly seen in the pancreatic adenocarcinoma. All these cases were misclassified by FNA as adenocarcinoma (2 cases) or suspicious for carcinoma (1 case) and were histologically confirmed to be oncocytic variants of PanNET. Conclusions: Useful salient features of the oncocytic variant of PanNET include abundant eosinophilic granular cytoplasm, finely granular chromatin, and relatively smooth nuclear membrane. The awareness of this variant will help to avoid misdiagnosis.",
keywords = "Endoscopic ultrasound, Fine needle aspiration, Oncocytic variant of pancreatic neuroendocrine tumor",
author = "Shaoxiong Chen and Xiaoyan Wang and Jingmei Lin",
year = "2014",
doi = "10.1159/000357035",
language = "English",
volume = "58",
pages = "131--137",
journal = "Acta Cytologica",
issn = "0001-5547",
publisher = "Science Printers and Publishers Inc.",
number = "2",

}

TY - JOUR

T1 - Fine needle aspiration of oncocytic variants of pancreatic neuroendocrine tumor

T2 - A report of three misdiagnosed cases

AU - Chen, Shaoxiong

AU - Wang, Xiaoyan

AU - Lin, Jingmei

PY - 2014

Y1 - 2014

N2 - Objectives: An oncocytic variant of pancreatic neuroendocrine tumors (PanNET) is exceedingly rare. Here we report cytomorphological features of the oncocytic variant of PanNET and discuss how to avoid diagnostic pitfalls. Study Design: A computerized search of our laboratory information system was performed over an 18-year period to identify all cytology and surgical pathology cases where a diagnosis of PanNET was made or considered in the differential diagnosis. Three cases of the oncocytic variant of PanNET were identified. Results: Endoscopic ultrasound-guided fine needle aspiration (FNA) smears showed cohesive clusters of large atypical cells with abundant eosinophilic granular cytoplasm, anisonucleosis, nuclear enlargement and overlapping, prominent nucleoli, and a relatively smooth nuclear membrane. Nuclei were round to oval with finely granular chromatin. Additional features included rare isolated cells and glandular formation. Some of these morphological features, such as anisonucleosis, nuclear enlargement, and overlapping, prominent nucleoli, are also commonly seen in the pancreatic adenocarcinoma. All these cases were misclassified by FNA as adenocarcinoma (2 cases) or suspicious for carcinoma (1 case) and were histologically confirmed to be oncocytic variants of PanNET. Conclusions: Useful salient features of the oncocytic variant of PanNET include abundant eosinophilic granular cytoplasm, finely granular chromatin, and relatively smooth nuclear membrane. The awareness of this variant will help to avoid misdiagnosis.

AB - Objectives: An oncocytic variant of pancreatic neuroendocrine tumors (PanNET) is exceedingly rare. Here we report cytomorphological features of the oncocytic variant of PanNET and discuss how to avoid diagnostic pitfalls. Study Design: A computerized search of our laboratory information system was performed over an 18-year period to identify all cytology and surgical pathology cases where a diagnosis of PanNET was made or considered in the differential diagnosis. Three cases of the oncocytic variant of PanNET were identified. Results: Endoscopic ultrasound-guided fine needle aspiration (FNA) smears showed cohesive clusters of large atypical cells with abundant eosinophilic granular cytoplasm, anisonucleosis, nuclear enlargement and overlapping, prominent nucleoli, and a relatively smooth nuclear membrane. Nuclei were round to oval with finely granular chromatin. Additional features included rare isolated cells and glandular formation. Some of these morphological features, such as anisonucleosis, nuclear enlargement, and overlapping, prominent nucleoli, are also commonly seen in the pancreatic adenocarcinoma. All these cases were misclassified by FNA as adenocarcinoma (2 cases) or suspicious for carcinoma (1 case) and were histologically confirmed to be oncocytic variants of PanNET. Conclusions: Useful salient features of the oncocytic variant of PanNET include abundant eosinophilic granular cytoplasm, finely granular chromatin, and relatively smooth nuclear membrane. The awareness of this variant will help to avoid misdiagnosis.

KW - Endoscopic ultrasound

KW - Fine needle aspiration

KW - Oncocytic variant of pancreatic neuroendocrine tumor

UR - http://www.scopus.com/inward/record.url?scp=84897079796&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84897079796&partnerID=8YFLogxK

U2 - 10.1159/000357035

DO - 10.1159/000357035

M3 - Article

VL - 58

SP - 131

EP - 137

JO - Acta Cytologica

JF - Acta Cytologica

SN - 0001-5547

IS - 2

ER -