Fish consumption and incidence of stroke: A meta-analysis of cohort studies

Ka He, Yiqing Song, Martha L. Daviglus, Kiang Liu, Linda Van Horn, Alan R. Dyer, Uri Goldbourt, Philip Greenland

Research output: Contribution to journalArticle

259 Citations (Scopus)

Abstract

Background and Purpose - Results from observational studies on fish consumption and risk of stroke are inconsistent. We quantitatively assessed the relationship between fish intake and incidence of stroke using a meta-analysis of cohort studies. Methods - We searched the Medline and Embase databases (1966 through October 2003) and identified 9 independent cohorts (from 8 studies) that provided a relative risk (RR) and corresponding 95% CI for total or any type of stroke in relation to fish consumption. Pooled RR and 95% CI of stroke were estimated by variance-based meta-analysis. Results - Compared with those who never consumed fish or ate fish less than once per month, the pooled RRs for total stroke were 0.91 (95% CI, 0.79 to 1.06) for individuals with fish intake 1 to 3 times per month, 0.87 (95% CI, 0.77 to 0.98) for once per week, 0.82 (95% CI, 0.72 to 0.94) for 2 to 4 times per week, and 0.69 (95% CI, 0.54 to 0.88) for ≥5 times per week (P for trend=0.06). In stratified analyses of 3 large cohort studies with data on stroke subtypes, the pooled RRs across 5 categories of fish intake were 1.0, 0.69 (95% CI, 0.48 to 0.99), 0.68 (95% CI, 0.52 to 0.88), 0.66 (95% CI, 0.51 to 0.87), and 0.65 (95% CI, 0.46 to 0.93) for ischemic stroke (P for trend=0.24); and 1.0, 1.47 (95% CI, 0.81 to 2.69), 1.21 (95% CI, 0.78 to 1.85), 0.89 (95% CI, 0.56 to 1.40), and 0.80 (95% CI, 0.44 to 1.47) for hemorrhagic stroke (P for trend=0.31). Conclusions - These results suggest that intake of fish is inversely related to risk of stroke, particularly ischemic stroke. Fish consumption as seldom as 1 to 3 times per month may protect against the incidence of ischemic stroke.

Original languageEnglish (US)
Pages (from-to)1538-1542
Number of pages5
JournalStroke
Volume35
Issue number7
DOIs
StatePublished - Jul 1 2004
Externally publishedYes

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Meta-Analysis
Fishes
Cohort Studies
Stroke
Incidence
Observational Studies
Databases

Keywords

  • Cerebrovascular accident
  • Fishes
  • Meta-analysis

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing

Cite this

He, K., Song, Y., Daviglus, M. L., Liu, K., Van Horn, L., Dyer, A. R., ... Greenland, P. (2004). Fish consumption and incidence of stroke: A meta-analysis of cohort studies. Stroke, 35(7), 1538-1542. https://doi.org/10.1161/01.STR.0000130856.31468.47

Fish consumption and incidence of stroke : A meta-analysis of cohort studies. / He, Ka; Song, Yiqing; Daviglus, Martha L.; Liu, Kiang; Van Horn, Linda; Dyer, Alan R.; Goldbourt, Uri; Greenland, Philip.

In: Stroke, Vol. 35, No. 7, 01.07.2004, p. 1538-1542.

Research output: Contribution to journalArticle

He, K, Song, Y, Daviglus, ML, Liu, K, Van Horn, L, Dyer, AR, Goldbourt, U & Greenland, P 2004, 'Fish consumption and incidence of stroke: A meta-analysis of cohort studies', Stroke, vol. 35, no. 7, pp. 1538-1542. https://doi.org/10.1161/01.STR.0000130856.31468.47
He, Ka ; Song, Yiqing ; Daviglus, Martha L. ; Liu, Kiang ; Van Horn, Linda ; Dyer, Alan R. ; Goldbourt, Uri ; Greenland, Philip. / Fish consumption and incidence of stroke : A meta-analysis of cohort studies. In: Stroke. 2004 ; Vol. 35, No. 7. pp. 1538-1542.
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abstract = "Background and Purpose - Results from observational studies on fish consumption and risk of stroke are inconsistent. We quantitatively assessed the relationship between fish intake and incidence of stroke using a meta-analysis of cohort studies. Methods - We searched the Medline and Embase databases (1966 through October 2003) and identified 9 independent cohorts (from 8 studies) that provided a relative risk (RR) and corresponding 95{\%} CI for total or any type of stroke in relation to fish consumption. Pooled RR and 95{\%} CI of stroke were estimated by variance-based meta-analysis. Results - Compared with those who never consumed fish or ate fish less than once per month, the pooled RRs for total stroke were 0.91 (95{\%} CI, 0.79 to 1.06) for individuals with fish intake 1 to 3 times per month, 0.87 (95{\%} CI, 0.77 to 0.98) for once per week, 0.82 (95{\%} CI, 0.72 to 0.94) for 2 to 4 times per week, and 0.69 (95{\%} CI, 0.54 to 0.88) for ≥5 times per week (P for trend=0.06). In stratified analyses of 3 large cohort studies with data on stroke subtypes, the pooled RRs across 5 categories of fish intake were 1.0, 0.69 (95{\%} CI, 0.48 to 0.99), 0.68 (95{\%} CI, 0.52 to 0.88), 0.66 (95{\%} CI, 0.51 to 0.87), and 0.65 (95{\%} CI, 0.46 to 0.93) for ischemic stroke (P for trend=0.24); and 1.0, 1.47 (95{\%} CI, 0.81 to 2.69), 1.21 (95{\%} CI, 0.78 to 1.85), 0.89 (95{\%} CI, 0.56 to 1.40), and 0.80 (95{\%} CI, 0.44 to 1.47) for hemorrhagic stroke (P for trend=0.31). Conclusions - These results suggest that intake of fish is inversely related to risk of stroke, particularly ischemic stroke. Fish consumption as seldom as 1 to 3 times per month may protect against the incidence of ischemic stroke.",
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AU - Van Horn, Linda

AU - Dyer, Alan R.

AU - Goldbourt, Uri

AU - Greenland, Philip

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N2 - Background and Purpose - Results from observational studies on fish consumption and risk of stroke are inconsistent. We quantitatively assessed the relationship between fish intake and incidence of stroke using a meta-analysis of cohort studies. Methods - We searched the Medline and Embase databases (1966 through October 2003) and identified 9 independent cohorts (from 8 studies) that provided a relative risk (RR) and corresponding 95% CI for total or any type of stroke in relation to fish consumption. Pooled RR and 95% CI of stroke were estimated by variance-based meta-analysis. Results - Compared with those who never consumed fish or ate fish less than once per month, the pooled RRs for total stroke were 0.91 (95% CI, 0.79 to 1.06) for individuals with fish intake 1 to 3 times per month, 0.87 (95% CI, 0.77 to 0.98) for once per week, 0.82 (95% CI, 0.72 to 0.94) for 2 to 4 times per week, and 0.69 (95% CI, 0.54 to 0.88) for ≥5 times per week (P for trend=0.06). In stratified analyses of 3 large cohort studies with data on stroke subtypes, the pooled RRs across 5 categories of fish intake were 1.0, 0.69 (95% CI, 0.48 to 0.99), 0.68 (95% CI, 0.52 to 0.88), 0.66 (95% CI, 0.51 to 0.87), and 0.65 (95% CI, 0.46 to 0.93) for ischemic stroke (P for trend=0.24); and 1.0, 1.47 (95% CI, 0.81 to 2.69), 1.21 (95% CI, 0.78 to 1.85), 0.89 (95% CI, 0.56 to 1.40), and 0.80 (95% CI, 0.44 to 1.47) for hemorrhagic stroke (P for trend=0.31). Conclusions - These results suggest that intake of fish is inversely related to risk of stroke, particularly ischemic stroke. Fish consumption as seldom as 1 to 3 times per month may protect against the incidence of ischemic stroke.

AB - Background and Purpose - Results from observational studies on fish consumption and risk of stroke are inconsistent. We quantitatively assessed the relationship between fish intake and incidence of stroke using a meta-analysis of cohort studies. Methods - We searched the Medline and Embase databases (1966 through October 2003) and identified 9 independent cohorts (from 8 studies) that provided a relative risk (RR) and corresponding 95% CI for total or any type of stroke in relation to fish consumption. Pooled RR and 95% CI of stroke were estimated by variance-based meta-analysis. Results - Compared with those who never consumed fish or ate fish less than once per month, the pooled RRs for total stroke were 0.91 (95% CI, 0.79 to 1.06) for individuals with fish intake 1 to 3 times per month, 0.87 (95% CI, 0.77 to 0.98) for once per week, 0.82 (95% CI, 0.72 to 0.94) for 2 to 4 times per week, and 0.69 (95% CI, 0.54 to 0.88) for ≥5 times per week (P for trend=0.06). In stratified analyses of 3 large cohort studies with data on stroke subtypes, the pooled RRs across 5 categories of fish intake were 1.0, 0.69 (95% CI, 0.48 to 0.99), 0.68 (95% CI, 0.52 to 0.88), 0.66 (95% CI, 0.51 to 0.87), and 0.65 (95% CI, 0.46 to 0.93) for ischemic stroke (P for trend=0.24); and 1.0, 1.47 (95% CI, 0.81 to 2.69), 1.21 (95% CI, 0.78 to 1.85), 0.89 (95% CI, 0.56 to 1.40), and 0.80 (95% CI, 0.44 to 1.47) for hemorrhagic stroke (P for trend=0.31). Conclusions - These results suggest that intake of fish is inversely related to risk of stroke, particularly ischemic stroke. Fish consumption as seldom as 1 to 3 times per month may protect against the incidence of ischemic stroke.

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