Fish consumption and risk of stroke and its subtypes

Accumulative evidence from a meta-analysis of prospective cohort studies

P. Xun, B. Qin, Yiqing Song, Y. Nakamura, T. Kurth, S. Yaemsiri, L. Djousse, K. He

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

BACKGROUND/OBJECTIVES:To provide a reliable assessment of the hypothesized association of fish consumption with stroke risk accumulatively, an updated meta-analysis of published prospective cohort studies was conducted.SUBJECTS/ METHODS:Prospective cohort studies through April 2012 in peer-reviewed journals indexed in MEDLINE and EMBASE were selected. Additional information was retrieved through Google or a search of the reference list in relevant articles. The main outcome measure was the weighted hazards ratio (HR) and corresponding 95% confidence interval (CI) for incident stroke according to fish consumption using a random-effects model.RESULTS:A database was derived from 16 eligible studies (19 cohorts), including 402 127 individuals (10 568 incident cases) with an average 12.8 years of follow-up. Compared with those who never consumed fish or ate fish 1/month, the pooled adjusted HRs of total stroke risk were 0.97 (95% CI, 0.871.08), 0.86 (0.800.93), 0.91 (0.850.98) and 0.87 (0.790.96) for those who consumed fish 13/month, 1/week, 24/week and 5/week, respectively (P linear trend 0.09; P nonlinear trend 0.02). Study location was a modifier. An inverse association between fish intake and stroke incidence was only found by studies conducted in North America. The modest inverse associations were more pronounced with ischemic stroke and were attenuated with hemorrhagic stroke.CONCLUSIONS:Accumulated evidence generated from this meta-analysis suggests that fish intake may have a protective effect against the risk of stroke, particularly ischemic stroke.

Original languageEnglish (US)
Pages (from-to)1199-1207
Number of pages9
JournalEuropean Journal of Clinical Nutrition
Volume66
Issue number11
DOIs
StatePublished - Nov 1 2012
Externally publishedYes

Fingerprint

Meta-Analysis
Fishes
Cohort Studies
Stroke
Prospective Studies
Confidence Intervals
North America
MEDLINE
Outcome Assessment (Health Care)
Databases
Incidence

Keywords

  • cohort studies
  • fish
  • meta-analysis
  • stroke

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Fish consumption and risk of stroke and its subtypes : Accumulative evidence from a meta-analysis of prospective cohort studies. / Xun, P.; Qin, B.; Song, Yiqing; Nakamura, Y.; Kurth, T.; Yaemsiri, S.; Djousse, L.; He, K.

In: European Journal of Clinical Nutrition, Vol. 66, No. 11, 01.11.2012, p. 1199-1207.

Research output: Contribution to journalArticle

Xun, P. ; Qin, B. ; Song, Yiqing ; Nakamura, Y. ; Kurth, T. ; Yaemsiri, S. ; Djousse, L. ; He, K. / Fish consumption and risk of stroke and its subtypes : Accumulative evidence from a meta-analysis of prospective cohort studies. In: European Journal of Clinical Nutrition. 2012 ; Vol. 66, No. 11. pp. 1199-1207.
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