Five-dimensional neuroimaging: Localization of the time-frequency dynamics of cortical activity

Sarang S. Dalal, Adrian G. Guggisberg, Erik Edwards, Kensuke Sekihara, Anne M. Findlay, Ryan T. Canolty, Mitchel S. Berger, Robert T. Knight, Nicholas Barbaro, Heidi E. Kirsch, Srikantan S. Nagarajan

Research output: Contribution to journalArticle

165 Citations (Scopus)

Abstract

The spatiotemporal dynamics of cortical oscillations across human brain regions remain poorly understood because of a lack of adequately validated methods for reconstructing such activity from noninvasive electrophysiological data. In this paper, we present a novel adaptive spatial filtering algorithm optimized for robust source time-frequency reconstruction from magnetoencephalography (MEG) and electroencephalography (EEG) data. The efficacy of the method is demonstrated with simulated sources and is also applied to real MEG data from a self-paced finger movement task. The algorithm reliably reveals modulations both in the beta band (12-30 Hz) and high gamma band (65-90 Hz) in sensorimotor cortex. The performance is validated by both across-subjects statistical comparisons and by intracranial electrocorticography (ECoG) data from two epilepsy patients. Interestingly, we also reliably observed high frequency activity (30-300 Hz) in the cerebellum, although with variable locations and frequencies across subjects. The proposed algorithm is highly parallelizable and runs efficiently on modern high-performance computing clusters. This method enables the ultimate promise of MEG and EEG for five-dimensional imaging of space, time, and frequency activity in the brain and renders it applicable for widespread studies of human cortical dynamics during cognition.

Original languageEnglish (US)
Pages (from-to)1686-1700
Number of pages15
JournalNeuroImage
Volume40
Issue number4
DOIs
StatePublished - May 1 2008
Externally publishedYes

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Magnetoencephalography
Neuroimaging
Electroencephalography
Computing Methodologies
Brain
Cerebellum
Cognition
Fingers
Epilepsy

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Neurology

Cite this

Dalal, S. S., Guggisberg, A. G., Edwards, E., Sekihara, K., Findlay, A. M., Canolty, R. T., ... Nagarajan, S. S. (2008). Five-dimensional neuroimaging: Localization of the time-frequency dynamics of cortical activity. NeuroImage, 40(4), 1686-1700. https://doi.org/10.1016/j.neuroimage.2008.01.023

Five-dimensional neuroimaging : Localization of the time-frequency dynamics of cortical activity. / Dalal, Sarang S.; Guggisberg, Adrian G.; Edwards, Erik; Sekihara, Kensuke; Findlay, Anne M.; Canolty, Ryan T.; Berger, Mitchel S.; Knight, Robert T.; Barbaro, Nicholas; Kirsch, Heidi E.; Nagarajan, Srikantan S.

In: NeuroImage, Vol. 40, No. 4, 01.05.2008, p. 1686-1700.

Research output: Contribution to journalArticle

Dalal, SS, Guggisberg, AG, Edwards, E, Sekihara, K, Findlay, AM, Canolty, RT, Berger, MS, Knight, RT, Barbaro, N, Kirsch, HE & Nagarajan, SS 2008, 'Five-dimensional neuroimaging: Localization of the time-frequency dynamics of cortical activity', NeuroImage, vol. 40, no. 4, pp. 1686-1700. https://doi.org/10.1016/j.neuroimage.2008.01.023
Dalal SS, Guggisberg AG, Edwards E, Sekihara K, Findlay AM, Canolty RT et al. Five-dimensional neuroimaging: Localization of the time-frequency dynamics of cortical activity. NeuroImage. 2008 May 1;40(4):1686-1700. https://doi.org/10.1016/j.neuroimage.2008.01.023
Dalal, Sarang S. ; Guggisberg, Adrian G. ; Edwards, Erik ; Sekihara, Kensuke ; Findlay, Anne M. ; Canolty, Ryan T. ; Berger, Mitchel S. ; Knight, Robert T. ; Barbaro, Nicholas ; Kirsch, Heidi E. ; Nagarajan, Srikantan S. / Five-dimensional neuroimaging : Localization of the time-frequency dynamics of cortical activity. In: NeuroImage. 2008 ; Vol. 40, No. 4. pp. 1686-1700.
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