Flow Cytometric DNA Analysis of PlacentalSite Trophoblastic Tumors

Patricia K. Kotylo, Helen Michael, Thomas E. Davis, Gregory P. Sutton, Paul R. Mark, Lawrence M. Roth

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

The placental-site trophoblastic tumor is a rare form of gestational trophoblastic neoplasia. Although originally considered benign, it is now apparent that this lesion can be associated with aggressive clinical behavior. Our study examined the DNA ploidy status and clinicopathologic features of four new cases of placental-site trophoblastic tumor. Three cases demonstrated diploid DNA stemlines with S-phase fractions ranging from 6 to 16%. These patients were alive and well at follow-up and had low-serum human chorionic gonadotrophin (hCG) levels. A fourth patient, who had a large tumor, demonstrated a tetraploid DNA peak with a prominent S-phase fraction. This patient exhibited an elevated serum hCG at limited follow-up. Flow cytometric DNA analysis may be a useful adjunct for the identification of placental-site trophoblastic tumors with malignant potential.

Original languageEnglish (US)
Pages (from-to)245-252
Number of pages8
JournalInternational Journal of Gynecological Pathology
Volume11
Issue number4
DOIs
StatePublished - Oct 1992

Keywords

  • DNA analysis
  • Flow cytometry
  • Placental-site trophoblastic tumor

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Pathology and Forensic Medicine

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