Flow Cytometric DNA Analysis of PlacentalSite Trophoblastic Tumors

Patricia K. Kotylo, Helen Michael, Thomas Davis, Gregory P. Sutton, Paul R. Mark, Lawrence M. Roth

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The placental-site trophoblastic tumor is a rare form of gestational trophoblastic neoplasia. Although originally considered benign, it is now apparent that this lesion can be associated with aggressive clinical behavior. Our study examined the DNA ploidy status and clinicopathologic features of four new cases of placental-site trophoblastic tumor. Three cases demonstrated diploid DNA stemlines with S-phase fractions ranging from 6 to 16%. These patients were alive and well at follow-up and had low-serum human chorionic gonadotrophin (hCG) levels. A fourth patient, who had a large tumor, demonstrated a tetraploid DNA peak with a prominent S-phase fraction. This patient exhibited an elevated serum hCG at limited follow-up. Flow cytometric DNA analysis may be a useful adjunct for the identification of placental-site trophoblastic tumors with malignant potential.

Original languageEnglish
Pages (from-to)245-252
Number of pages8
JournalInternational Journal of Gynecological Pathology
Volume11
Issue number4
StatePublished - 1992

Fingerprint

Trophoblastic Neoplasms
Placental Site Trophoblastic Tumor
DNA
Chorionic Gonadotropin
S Phase
Gestational Trophoblastic Disease
Tetraploidy
Ploidies
Serum
Diploidy
Neoplasms

Keywords

  • DNA analysis
  • Flow cytometry
  • Placental-site trophoblastic tumor

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Pathology and Forensic Medicine

Cite this

Kotylo, P. K., Michael, H., Davis, T., Sutton, G. P., Mark, P. R., & Roth, L. M. (1992). Flow Cytometric DNA Analysis of PlacentalSite Trophoblastic Tumors. International Journal of Gynecological Pathology, 11(4), 245-252.

Flow Cytometric DNA Analysis of PlacentalSite Trophoblastic Tumors. / Kotylo, Patricia K.; Michael, Helen; Davis, Thomas; Sutton, Gregory P.; Mark, Paul R.; Roth, Lawrence M.

In: International Journal of Gynecological Pathology, Vol. 11, No. 4, 1992, p. 245-252.

Research output: Contribution to journalArticle

Kotylo, PK, Michael, H, Davis, T, Sutton, GP, Mark, PR & Roth, LM 1992, 'Flow Cytometric DNA Analysis of PlacentalSite Trophoblastic Tumors', International Journal of Gynecological Pathology, vol. 11, no. 4, pp. 245-252.
Kotylo, Patricia K. ; Michael, Helen ; Davis, Thomas ; Sutton, Gregory P. ; Mark, Paul R. ; Roth, Lawrence M. / Flow Cytometric DNA Analysis of PlacentalSite Trophoblastic Tumors. In: International Journal of Gynecological Pathology. 1992 ; Vol. 11, No. 4. pp. 245-252.
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