Flow cytometry derived DNA content of the primary lesions of advanced germ cell tumours

G. W. Sledge, J. N. Eble, B. J. Roth, B. P. Wuhrman, L. H. Einhorn

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Abstract

We currently lack good prognostic indicators for patients with advanced disseminated germ cell tumours (GCT). An analysis of archival tumour samples of forty-nine patients with advanced GCT for flow cytometry derived DNA content suggests an inverse relationship between tumour proliferative activity and patient survival. The great majority of patients with advanced GCT have aneuploid tumour subpopulation. This analysis suggests that the survival of patients with advanced GCT may depend in part on kinetic variables present in the primary tumour.

Original languageEnglish (US)
Pages (from-to)115-120
Number of pages6
JournalInternational Journal of Andrology
Volume10
Issue number1 SPEC.
StatePublished - Jul 31 1987

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ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Reproductive Medicine
  • Urology

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