Flow limitation in normal infants

A new method for forced expiratory maneuvers from raised lung volumes

Andre Feher, Robert Castile, Jeff Kisling, Connie Angelicchio, Dave Filbrun, Robert Flucke, Robert Tepper

Research output: Contribution to journalArticle

94 Citations (Scopus)

Abstract

Forced expiratory maneuvers generated by rapid thoracic compression have been used to assess airway function in infants. It remains unclear whether flow limitation can be achieved in healthy infants because low pressure transmission across the chest wall and inspiratory effort may limit the maximum transpulmonary pressure developed during the maneuver. We have found that several rapid inflations to a lung volume set at an airway pressure of 30 cmH2O (V30) briefly inhibit respiratory effort and allow forced expiration to proceed from V30 to residual volume. We used a water-filled esophageal catheter to measure isovolume pressure-flow curves in seven healthy infants (3-33 mo). Forced vital capacity (FVC) was defined as the volume between V30 and residual volume. Pressure transmission between the compression jacket and the esophagus decreased with decreasing lung volume and averaged 60 and 37% at 50 and 75% of expired FVC, respectively. Subjects demonstrated plateaus in their isovolume pressure-flow curves at 50% of expired FVC and lower lung volumes. We conclude that this new methodology enables forced expiratory maneuvers to achieve flow limitation in healthy infants over at least the lower portion of their lung volume.

Original languageEnglish
Pages (from-to)2019-2025
Number of pages7
JournalJournal of Applied Physiology
Volume80
Issue number6
StatePublished - Jun 1996

Fingerprint

Pressure
Lung
Vital Capacity
Residual Volume
Economic Inflation
Thoracic Wall
Esophagus
Thorax
Catheters
Water

Keywords

  • forced expiratory flows
  • healthy infants
  • rapid-compression technique

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Feher, A., Castile, R., Kisling, J., Angelicchio, C., Filbrun, D., Flucke, R., & Tepper, R. (1996). Flow limitation in normal infants: A new method for forced expiratory maneuvers from raised lung volumes. Journal of Applied Physiology, 80(6), 2019-2025.

Flow limitation in normal infants : A new method for forced expiratory maneuvers from raised lung volumes. / Feher, Andre; Castile, Robert; Kisling, Jeff; Angelicchio, Connie; Filbrun, Dave; Flucke, Robert; Tepper, Robert.

In: Journal of Applied Physiology, Vol. 80, No. 6, 06.1996, p. 2019-2025.

Research output: Contribution to journalArticle

Feher, A, Castile, R, Kisling, J, Angelicchio, C, Filbrun, D, Flucke, R & Tepper, R 1996, 'Flow limitation in normal infants: A new method for forced expiratory maneuvers from raised lung volumes', Journal of Applied Physiology, vol. 80, no. 6, pp. 2019-2025.
Feher A, Castile R, Kisling J, Angelicchio C, Filbrun D, Flucke R et al. Flow limitation in normal infants: A new method for forced expiratory maneuvers from raised lung volumes. Journal of Applied Physiology. 1996 Jun;80(6):2019-2025.
Feher, Andre ; Castile, Robert ; Kisling, Jeff ; Angelicchio, Connie ; Filbrun, Dave ; Flucke, Robert ; Tepper, Robert. / Flow limitation in normal infants : A new method for forced expiratory maneuvers from raised lung volumes. In: Journal of Applied Physiology. 1996 ; Vol. 80, No. 6. pp. 2019-2025.
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