Flow limitation in normal infants

A new method for forced expiratory maneuvers from raised lung volumes

A. Feher, R. Castile, J. Kisling, C. Angelicchio, D. Filburn, R. Flucke, Robert Tepper

Research output: Contribution to journalArticle

Abstract

Forced expiratory maneuvers generated by rapid thoracic compression have been used to assess airway function in infants. It remains unclear whether flow limitation can be achieved in healthy infants because low pressure transmission across the chest wall and inspiratory effort may limit the maximum transpulmonary pressure developed during the maneuver. We have found that several rapid inflations to a lung volume set at an airway pressure of 30 cmH2O (V30) briefly inhibit respiratory effort and allow forced expiration to proceed from V30 to residual volume. We used a water-filled esophageal catheter to measure isovolume pressure-flow curves in seven healthy infants (3-33 mo). Forced vital capacity (FVC) was defined as the volume between V30 and residual volume. Pressure transmission between the compression jacket and the esophagus decreased with decreasing lung volume and averaged 60 and 37% at 50 and 75% of expired FVC, respectively. Subjects demonstrated plateaus in their isovolume pressure-flow curves at 50% of expired FVC and lower lung volumes. We conclude that this new methodology enables forced expiratory maneuvers to achieve flow limitation in healthy infants over at least the lower portion of their lung volume. Comments. This is an important new method for studying lung function of both normal infants and those with lung disease.

Original languageEnglish
Pages (from-to)320
Number of pages1
JournalPediatric Pulmonology
Volume23
Issue number4
StatePublished - 1997
Externally publishedYes

Fingerprint

Pressure
Lung
Vital Capacity
Residual Volume
Economic Inflation
Thoracic Wall
Esophagus
Lung Diseases
Thorax
Catheters
Water

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine

Cite this

Feher, A., Castile, R., Kisling, J., Angelicchio, C., Filburn, D., Flucke, R., & Tepper, R. (1997). Flow limitation in normal infants: A new method for forced expiratory maneuvers from raised lung volumes. Pediatric Pulmonology, 23(4), 320.

Flow limitation in normal infants : A new method for forced expiratory maneuvers from raised lung volumes. / Feher, A.; Castile, R.; Kisling, J.; Angelicchio, C.; Filburn, D.; Flucke, R.; Tepper, Robert.

In: Pediatric Pulmonology, Vol. 23, No. 4, 1997, p. 320.

Research output: Contribution to journalArticle

Feher, A, Castile, R, Kisling, J, Angelicchio, C, Filburn, D, Flucke, R & Tepper, R 1997, 'Flow limitation in normal infants: A new method for forced expiratory maneuvers from raised lung volumes', Pediatric Pulmonology, vol. 23, no. 4, pp. 320.
Feher A, Castile R, Kisling J, Angelicchio C, Filburn D, Flucke R et al. Flow limitation in normal infants: A new method for forced expiratory maneuvers from raised lung volumes. Pediatric Pulmonology. 1997;23(4):320.
Feher, A. ; Castile, R. ; Kisling, J. ; Angelicchio, C. ; Filburn, D. ; Flucke, R. ; Tepper, Robert. / Flow limitation in normal infants : A new method for forced expiratory maneuvers from raised lung volumes. In: Pediatric Pulmonology. 1997 ; Vol. 23, No. 4. pp. 320.
@article{bbc0afcd96584bdf9542e0b13afdfd57,
title = "Flow limitation in normal infants: A new method for forced expiratory maneuvers from raised lung volumes",
abstract = "Forced expiratory maneuvers generated by rapid thoracic compression have been used to assess airway function in infants. It remains unclear whether flow limitation can be achieved in healthy infants because low pressure transmission across the chest wall and inspiratory effort may limit the maximum transpulmonary pressure developed during the maneuver. We have found that several rapid inflations to a lung volume set at an airway pressure of 30 cmH2O (V30) briefly inhibit respiratory effort and allow forced expiration to proceed from V30 to residual volume. We used a water-filled esophageal catheter to measure isovolume pressure-flow curves in seven healthy infants (3-33 mo). Forced vital capacity (FVC) was defined as the volume between V30 and residual volume. Pressure transmission between the compression jacket and the esophagus decreased with decreasing lung volume and averaged 60 and 37{\%} at 50 and 75{\%} of expired FVC, respectively. Subjects demonstrated plateaus in their isovolume pressure-flow curves at 50{\%} of expired FVC and lower lung volumes. We conclude that this new methodology enables forced expiratory maneuvers to achieve flow limitation in healthy infants over at least the lower portion of their lung volume. Comments. This is an important new method for studying lung function of both normal infants and those with lung disease.",
author = "A. Feher and R. Castile and J. Kisling and C. Angelicchio and D. Filburn and R. Flucke and Robert Tepper",
year = "1997",
language = "English",
volume = "23",
pages = "320",
journal = "Pediatric Pulmonology",
issn = "8755-6863",
publisher = "Wiley-Liss Inc.",
number = "4",

}

TY - JOUR

T1 - Flow limitation in normal infants

T2 - A new method for forced expiratory maneuvers from raised lung volumes

AU - Feher, A.

AU - Castile, R.

AU - Kisling, J.

AU - Angelicchio, C.

AU - Filburn, D.

AU - Flucke, R.

AU - Tepper, Robert

PY - 1997

Y1 - 1997

N2 - Forced expiratory maneuvers generated by rapid thoracic compression have been used to assess airway function in infants. It remains unclear whether flow limitation can be achieved in healthy infants because low pressure transmission across the chest wall and inspiratory effort may limit the maximum transpulmonary pressure developed during the maneuver. We have found that several rapid inflations to a lung volume set at an airway pressure of 30 cmH2O (V30) briefly inhibit respiratory effort and allow forced expiration to proceed from V30 to residual volume. We used a water-filled esophageal catheter to measure isovolume pressure-flow curves in seven healthy infants (3-33 mo). Forced vital capacity (FVC) was defined as the volume between V30 and residual volume. Pressure transmission between the compression jacket and the esophagus decreased with decreasing lung volume and averaged 60 and 37% at 50 and 75% of expired FVC, respectively. Subjects demonstrated plateaus in their isovolume pressure-flow curves at 50% of expired FVC and lower lung volumes. We conclude that this new methodology enables forced expiratory maneuvers to achieve flow limitation in healthy infants over at least the lower portion of their lung volume. Comments. This is an important new method for studying lung function of both normal infants and those with lung disease.

AB - Forced expiratory maneuvers generated by rapid thoracic compression have been used to assess airway function in infants. It remains unclear whether flow limitation can be achieved in healthy infants because low pressure transmission across the chest wall and inspiratory effort may limit the maximum transpulmonary pressure developed during the maneuver. We have found that several rapid inflations to a lung volume set at an airway pressure of 30 cmH2O (V30) briefly inhibit respiratory effort and allow forced expiration to proceed from V30 to residual volume. We used a water-filled esophageal catheter to measure isovolume pressure-flow curves in seven healthy infants (3-33 mo). Forced vital capacity (FVC) was defined as the volume between V30 and residual volume. Pressure transmission between the compression jacket and the esophagus decreased with decreasing lung volume and averaged 60 and 37% at 50 and 75% of expired FVC, respectively. Subjects demonstrated plateaus in their isovolume pressure-flow curves at 50% of expired FVC and lower lung volumes. We conclude that this new methodology enables forced expiratory maneuvers to achieve flow limitation in healthy infants over at least the lower portion of their lung volume. Comments. This is an important new method for studying lung function of both normal infants and those with lung disease.

UR - http://www.scopus.com/inward/record.url?scp=33748136022&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33748136022&partnerID=8YFLogxK

M3 - Article

VL - 23

SP - 320

JO - Pediatric Pulmonology

JF - Pediatric Pulmonology

SN - 8755-6863

IS - 4

ER -