Flt3 ligand

M. L. Capitano, S. Zhang, H. E. Broxmeyer

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Flt3 ligand (FL) is a transmembrane protein that binds to Flt3, a fms-like tyrosine kinase three receptor, and triggers the intracellular signaling cascade that leads to the proliferation and development of hematopoietic stem cells and progenitor cells as well as the development of the immune system. For most activities, FL has modest effects by itself; however, FL manifests potent co-stimulating activity and actively synergizes with other cytokines for optimal biological effects.

Original languageEnglish (US)
Title of host publicationThe Curated Reference Collection in Neuroscience and Biobehavioral Psychology
PublisherElsevier Science Ltd.
Pages637-644
Number of pages8
ISBN (Electronic)9780128093245
DOIs
StatePublished - Jan 1 2016

Keywords

  • B cells
  • Dendritic cells
  • Flt3
  • Flt3 ligand
  • Hematopoiesis
  • Hematopoietic progenitor cell
  • Hematopoietic stem cell
  • Myeloid-derived suppressor cells
  • Natural killer cells
  • Regulatory T cells
  • T cells

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Capitano, M. L., Zhang, S., & Broxmeyer, H. E. (2016). Flt3 ligand. In The Curated Reference Collection in Neuroscience and Biobehavioral Psychology (pp. 637-644). Elsevier Science Ltd.. https://doi.org/10.1016/B978-0-12-809324-5.03249-1