Fluidity of insulin action

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Unlike the intensive research in pursuit of understanding the molecular mechanisms of insulin signaling and resistance to its biological action associated most significantly with obesity and type 2 diabetes, the influence of the plasma membrane on insulin sensitivity has been intermittently studied over the years - mainly because it was thought that mediators of insulin action, such as the insulin receptor and the insulin-responsive glucose transporter GLUT4, localize more or less uniformly in the lipids that form cell membranes. Recent insights into membrane physiology suggest that the plasma membrane impacts the function of membrane proteins mediating insulin action. Furthermore, membrane disturbances may be the basis of insulin resistance. Relevant insulin signal transduction data in terms of plasma membrane and insulin resistance are the focus of this review. The discussion visits the cell membrane hypothesis of insulin resistance that suggests insulin action could be related to changes in cell membrane properties.

Original languageEnglish (US)
Pages (from-to)127-138
Number of pages12
JournalApplied Biochemistry and Biotechnology - Part B Molecular Biotechnology
Volume27
Issue number2
DOIs
StatePublished - Dec 1 2004

Fingerprint

Fluidity
Insulin
Insulin Resistance
Cell Membrane
Cell membranes
Glucose Transporter Type 4
Membranes
Insulin Receptor
Membrane Lipids
Type 2 Diabetes Mellitus
Signal Transduction
Membrane Proteins
Obesity
Signal transduction
Physiology
Medical problems
Research
Lipids
Glucose
Proteins

Keywords

  • Diabetes
  • Glucose transport
  • GLUT4
  • Insulin mimetic stimuli
  • Insulin resistance
  • Insulin signaling
  • Membrane fluidity
  • Obesity
  • Plasma membrane
  • SNARE proteins

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Biotechnology
  • Applied Microbiology and Biotechnology
  • Bioengineering

Cite this

Fluidity of insulin action. / Elmendorf, Jeffrey S.

In: Applied Biochemistry and Biotechnology - Part B Molecular Biotechnology, Vol. 27, No. 2, 01.12.2004, p. 127-138.

Research output: Contribution to journalArticle

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