Fluorescein fluorescence use in the management of intracranial neoplastic and vascular lesions

A review and report of a new technique

Brandon C. Lane, Aaron Cohen-Gadol

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The use of fluorescent technologies in neurosurgery has a substantial history with applications to vascular and tumor surgery dating back to the 1940s. This review focuses on the applications of fluorescence imaging to intracranial vascular and neoplastic lesions using sodium fluorescein. The authors performed a literature search for articles about the use of sodium fluorescein in neurosurgery. Fifty-five articles were initially retrieved, and 37 of these were appropriate for this review. The subcategorization of these articles revealed 2 describing the properties of fluorescein, 19 articles relating to applications of fluorescein to tumor, 11 relating to vascular applications, and 5 reporting side effects associated with fluorescein use. Articles related to use of this agent in evaluation of CSF leak were excluded. Sodium fluorescein has been reported to be a useful surgical adjunct in resection of neoplastic lesions based on differential fluorescence between normal and neoplastic tissue. There are many reports on the utility of fluorescein in vascular imaging relating to arteriovenous malformations, aneurysms, and vessel anastomosis; however, these reports do not examine primary outcomes. Sodium fluorescein has been judged as generally safe with few reports of severe complications. Sodium fluorescein has demonstrated promise as a useful surgical adjunct in neurosurgery for vascular and neoplastic lesions. It is well tolerated, but further study is required to determine its full utility. Finally, we will introduce a new practical technology that could potentially improve intraoperative application of sodium fluorescein by improving its fluorescence visualization while using substantially lower doses of this dye.

Original languageEnglish
Pages (from-to)160-169
Number of pages10
JournalCurrent Drug Discovery Technologies
Volume10
Issue number2
DOIs
StatePublished - Jun 2013

Fingerprint

Fluorescein
Blood Vessels
Fluorescence
Neurosurgery
Technology
Arteriovenous Malformations
Optical Imaging
Arteriovenous Fistula
Neoplasms
Coloring Agents
History

Keywords

  • Brain neoplasms
  • Clip ligation
  • Extent of resection
  • Fluorescein
  • Fluorescence
  • Intracranial aneurysm
  • Neurosurgical procedures
  • Surgical instruments
  • Therapeutics
  • Treatment outcome

ASJC Scopus subject areas

  • Drug Discovery

Cite this

@article{32bae5330e7e4b999897d2fdfc4dff0d,
title = "Fluorescein fluorescence use in the management of intracranial neoplastic and vascular lesions: A review and report of a new technique",
abstract = "The use of fluorescent technologies in neurosurgery has a substantial history with applications to vascular and tumor surgery dating back to the 1940s. This review focuses on the applications of fluorescence imaging to intracranial vascular and neoplastic lesions using sodium fluorescein. The authors performed a literature search for articles about the use of sodium fluorescein in neurosurgery. Fifty-five articles were initially retrieved, and 37 of these were appropriate for this review. The subcategorization of these articles revealed 2 describing the properties of fluorescein, 19 articles relating to applications of fluorescein to tumor, 11 relating to vascular applications, and 5 reporting side effects associated with fluorescein use. Articles related to use of this agent in evaluation of CSF leak were excluded. Sodium fluorescein has been reported to be a useful surgical adjunct in resection of neoplastic lesions based on differential fluorescence between normal and neoplastic tissue. There are many reports on the utility of fluorescein in vascular imaging relating to arteriovenous malformations, aneurysms, and vessel anastomosis; however, these reports do not examine primary outcomes. Sodium fluorescein has been judged as generally safe with few reports of severe complications. Sodium fluorescein has demonstrated promise as a useful surgical adjunct in neurosurgery for vascular and neoplastic lesions. It is well tolerated, but further study is required to determine its full utility. Finally, we will introduce a new practical technology that could potentially improve intraoperative application of sodium fluorescein by improving its fluorescence visualization while using substantially lower doses of this dye.",
keywords = "Brain neoplasms, Clip ligation, Extent of resection, Fluorescein, Fluorescence, Intracranial aneurysm, Neurosurgical procedures, Surgical instruments, Therapeutics, Treatment outcome",
author = "Lane, {Brandon C.} and Aaron Cohen-Gadol",
year = "2013",
month = "6",
doi = "10.2174/1570163811310020009",
language = "English",
volume = "10",
pages = "160--169",
journal = "Current Drug Discovery Technologies",
issn = "1570-1638",
publisher = "Bentham Science Publishers B.V.",
number = "2",

}

TY - JOUR

T1 - Fluorescein fluorescence use in the management of intracranial neoplastic and vascular lesions

T2 - A review and report of a new technique

AU - Lane, Brandon C.

AU - Cohen-Gadol, Aaron

PY - 2013/6

Y1 - 2013/6

N2 - The use of fluorescent technologies in neurosurgery has a substantial history with applications to vascular and tumor surgery dating back to the 1940s. This review focuses on the applications of fluorescence imaging to intracranial vascular and neoplastic lesions using sodium fluorescein. The authors performed a literature search for articles about the use of sodium fluorescein in neurosurgery. Fifty-five articles were initially retrieved, and 37 of these were appropriate for this review. The subcategorization of these articles revealed 2 describing the properties of fluorescein, 19 articles relating to applications of fluorescein to tumor, 11 relating to vascular applications, and 5 reporting side effects associated with fluorescein use. Articles related to use of this agent in evaluation of CSF leak were excluded. Sodium fluorescein has been reported to be a useful surgical adjunct in resection of neoplastic lesions based on differential fluorescence between normal and neoplastic tissue. There are many reports on the utility of fluorescein in vascular imaging relating to arteriovenous malformations, aneurysms, and vessel anastomosis; however, these reports do not examine primary outcomes. Sodium fluorescein has been judged as generally safe with few reports of severe complications. Sodium fluorescein has demonstrated promise as a useful surgical adjunct in neurosurgery for vascular and neoplastic lesions. It is well tolerated, but further study is required to determine its full utility. Finally, we will introduce a new practical technology that could potentially improve intraoperative application of sodium fluorescein by improving its fluorescence visualization while using substantially lower doses of this dye.

AB - The use of fluorescent technologies in neurosurgery has a substantial history with applications to vascular and tumor surgery dating back to the 1940s. This review focuses on the applications of fluorescence imaging to intracranial vascular and neoplastic lesions using sodium fluorescein. The authors performed a literature search for articles about the use of sodium fluorescein in neurosurgery. Fifty-five articles were initially retrieved, and 37 of these were appropriate for this review. The subcategorization of these articles revealed 2 describing the properties of fluorescein, 19 articles relating to applications of fluorescein to tumor, 11 relating to vascular applications, and 5 reporting side effects associated with fluorescein use. Articles related to use of this agent in evaluation of CSF leak were excluded. Sodium fluorescein has been reported to be a useful surgical adjunct in resection of neoplastic lesions based on differential fluorescence between normal and neoplastic tissue. There are many reports on the utility of fluorescein in vascular imaging relating to arteriovenous malformations, aneurysms, and vessel anastomosis; however, these reports do not examine primary outcomes. Sodium fluorescein has been judged as generally safe with few reports of severe complications. Sodium fluorescein has demonstrated promise as a useful surgical adjunct in neurosurgery for vascular and neoplastic lesions. It is well tolerated, but further study is required to determine its full utility. Finally, we will introduce a new practical technology that could potentially improve intraoperative application of sodium fluorescein by improving its fluorescence visualization while using substantially lower doses of this dye.

KW - Brain neoplasms

KW - Clip ligation

KW - Extent of resection

KW - Fluorescein

KW - Fluorescence

KW - Intracranial aneurysm

KW - Neurosurgical procedures

KW - Surgical instruments

KW - Therapeutics

KW - Treatment outcome

UR - http://www.scopus.com/inward/record.url?scp=84882407490&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84882407490&partnerID=8YFLogxK

U2 - 10.2174/1570163811310020009

DO - 10.2174/1570163811310020009

M3 - Article

VL - 10

SP - 160

EP - 169

JO - Current Drug Discovery Technologies

JF - Current Drug Discovery Technologies

SN - 1570-1638

IS - 2

ER -