Fluorescent cytogenetics of renal cell neoplasms

M. Brunelli, S. Gobbo, P. Cossu-Rocca, Liang Cheng, V. Ficarra, G. Novara, F. Menestrina, M. Chilosi, Guido Martignont

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Renal cell neoplasms are a heterogeneous group of tumours in terms of pathological features and prognostic behaviour. The genetics of these tumours may aid in correct diagnosis and accurate assessment of prognosis. In ambiguous cases it may be necessary to utilise new markers that are capable of further discerning renal cell neoplasms. Fluorescence in situ hybridization (FISH) on formalin-fixed, paraffin-embedded tissue is an increasingly useful technique in the detection of many diagnostic chromosomal abnormalities, among which chromosomes 1, 2, 3p, 6, 7, 10, 17 and Y are the most common. The addition of FISH to histological evaluation improves the diagnostic accuracy of core biopsies from renal masses, which may have an important impact in clinical management of many cases due to newer therapeutic approaches, including cryo- or radiofrequency ablation, nephron-sparing surgeries and target therapies.

Original languageEnglish
Pages (from-to)454-460
Number of pages7
JournalPathologica
Volume100
Issue number6
StatePublished - Dec 2008

Fingerprint

Kidney Neoplasms
Fluorescence In Situ Hybridization
Cytogenetics
Chromosomes, Human, Pair 2
Chromosomes, Human, Pair 1
Nephrons
Case Management
Chromosome Aberrations
Paraffin
Formaldehyde
Neoplasms
Kidney
Biopsy
Therapeutics

Keywords

  • FISH
  • Fluorescence in situ hybridization
  • Interphase cytogenetic
  • Renal cell neoplasm

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Brunelli, M., Gobbo, S., Cossu-Rocca, P., Cheng, L., Ficarra, V., Novara, G., ... Martignont, G. (2008). Fluorescent cytogenetics of renal cell neoplasms. Pathologica, 100(6), 454-460.

Fluorescent cytogenetics of renal cell neoplasms. / Brunelli, M.; Gobbo, S.; Cossu-Rocca, P.; Cheng, Liang; Ficarra, V.; Novara, G.; Menestrina, F.; Chilosi, M.; Martignont, Guido.

In: Pathologica, Vol. 100, No. 6, 12.2008, p. 454-460.

Research output: Contribution to journalArticle

Brunelli, M, Gobbo, S, Cossu-Rocca, P, Cheng, L, Ficarra, V, Novara, G, Menestrina, F, Chilosi, M & Martignont, G 2008, 'Fluorescent cytogenetics of renal cell neoplasms', Pathologica, vol. 100, no. 6, pp. 454-460.
Brunelli M, Gobbo S, Cossu-Rocca P, Cheng L, Ficarra V, Novara G et al. Fluorescent cytogenetics of renal cell neoplasms. Pathologica. 2008 Dec;100(6):454-460.
Brunelli, M. ; Gobbo, S. ; Cossu-Rocca, P. ; Cheng, Liang ; Ficarra, V. ; Novara, G. ; Menestrina, F. ; Chilosi, M. ; Martignont, Guido. / Fluorescent cytogenetics of renal cell neoplasms. In: Pathologica. 2008 ; Vol. 100, No. 6. pp. 454-460.
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