Fluoroquinolone susceptibility, resistance, and pharmacodynamics versus clinical isolates of Streptococcus pneumoniae from Indiana

Michael B. Kays, Gerald Denys

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The in vitro activity and pharmacodynamics (AUC0-24/MIC) of levofloxacin, gatifloxacin, moxifloxacin, and gemifloxacin were evaluated against 307 clinical isolates of Streptococcus pneumoniae from Indianapolis, Indiana. Organisms were collected between January 1999 and April 2000, and MICs were determined by broth microdilution. Serum concentration-time profiles were simulated for the following oral regimens administered once daily: levofloxacin 500 mg and 750 mg; gatifloxacin 400 mg; moxifloxacin 400 mg; gemifloxacin 320 mg. Free 24 h area under the serum concentration-time curves (AUC0-24) were calculated, and the average AUC0-24/MIC was calculated for each regimen. Differences in AUC0-24/MIC among agents were determined by analysis of variance (Scheffe post-hoc test, p < 0.05). Overall, gemifloxacin was the most potent agent tested. Five (1.7%), 4 (1.3%), and 2 (0.7%) isolates were resistant to levofloxacin, gatifloxacin, and moxifloxacin, respectively. None of the isolates was resistant to gemifloxacin. Gemifloxacin AUC0-24/MIC was significantly greater than all other regimens (p<0.0001), with the exception of moxifloxacin. However, the percent of isolates for which an AUC0-24/MIC ≥30-50 can be achieved is similar for gemifloxacin, moxifloxacin, gatifloxacin, and levofloxacin 750 mg. Large comparative studies are needed to determine if the differences in AUC0-24/MIC among fluoroquinolones are clinically significant.

Original languageEnglish (US)
Pages (from-to)193-198
Number of pages6
JournalDiagnostic Microbiology and Infectious Disease
Volume40
Issue number4
DOIs
StatePublished - Jan 1 2001

Fingerprint

Fluoroquinolones
Streptococcus pneumoniae
Levofloxacin
Serum
gemifloxacin
Analysis of Variance
moxifloxacin
gatifloxacin

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

@article{5bc02d931ac246c88c3e9838e45e2ade,
title = "Fluoroquinolone susceptibility, resistance, and pharmacodynamics versus clinical isolates of Streptococcus pneumoniae from Indiana",
abstract = "The in vitro activity and pharmacodynamics (AUC0-24/MIC) of levofloxacin, gatifloxacin, moxifloxacin, and gemifloxacin were evaluated against 307 clinical isolates of Streptococcus pneumoniae from Indianapolis, Indiana. Organisms were collected between January 1999 and April 2000, and MICs were determined by broth microdilution. Serum concentration-time profiles were simulated for the following oral regimens administered once daily: levofloxacin 500 mg and 750 mg; gatifloxacin 400 mg; moxifloxacin 400 mg; gemifloxacin 320 mg. Free 24 h area under the serum concentration-time curves (AUC0-24) were calculated, and the average AUC0-24/MIC was calculated for each regimen. Differences in AUC0-24/MIC among agents were determined by analysis of variance (Scheffe post-hoc test, p < 0.05). Overall, gemifloxacin was the most potent agent tested. Five (1.7{\%}), 4 (1.3{\%}), and 2 (0.7{\%}) isolates were resistant to levofloxacin, gatifloxacin, and moxifloxacin, respectively. None of the isolates was resistant to gemifloxacin. Gemifloxacin AUC0-24/MIC was significantly greater than all other regimens (p<0.0001), with the exception of moxifloxacin. However, the percent of isolates for which an AUC0-24/MIC ≥30-50 can be achieved is similar for gemifloxacin, moxifloxacin, gatifloxacin, and levofloxacin 750 mg. Large comparative studies are needed to determine if the differences in AUC0-24/MIC among fluoroquinolones are clinically significant.",
author = "Kays, {Michael B.} and Gerald Denys",
year = "2001",
month = "1",
day = "1",
doi = "10.1016/S0732-8893(01)00277-2",
language = "English (US)",
volume = "40",
pages = "193--198",
journal = "Diagnostic Microbiology and Infectious Disease",
issn = "0732-8893",
publisher = "Elsevier Inc.",
number = "4",

}

TY - JOUR

T1 - Fluoroquinolone susceptibility, resistance, and pharmacodynamics versus clinical isolates of Streptococcus pneumoniae from Indiana

AU - Kays, Michael B.

AU - Denys, Gerald

PY - 2001/1/1

Y1 - 2001/1/1

N2 - The in vitro activity and pharmacodynamics (AUC0-24/MIC) of levofloxacin, gatifloxacin, moxifloxacin, and gemifloxacin were evaluated against 307 clinical isolates of Streptococcus pneumoniae from Indianapolis, Indiana. Organisms were collected between January 1999 and April 2000, and MICs were determined by broth microdilution. Serum concentration-time profiles were simulated for the following oral regimens administered once daily: levofloxacin 500 mg and 750 mg; gatifloxacin 400 mg; moxifloxacin 400 mg; gemifloxacin 320 mg. Free 24 h area under the serum concentration-time curves (AUC0-24) were calculated, and the average AUC0-24/MIC was calculated for each regimen. Differences in AUC0-24/MIC among agents were determined by analysis of variance (Scheffe post-hoc test, p < 0.05). Overall, gemifloxacin was the most potent agent tested. Five (1.7%), 4 (1.3%), and 2 (0.7%) isolates were resistant to levofloxacin, gatifloxacin, and moxifloxacin, respectively. None of the isolates was resistant to gemifloxacin. Gemifloxacin AUC0-24/MIC was significantly greater than all other regimens (p<0.0001), with the exception of moxifloxacin. However, the percent of isolates for which an AUC0-24/MIC ≥30-50 can be achieved is similar for gemifloxacin, moxifloxacin, gatifloxacin, and levofloxacin 750 mg. Large comparative studies are needed to determine if the differences in AUC0-24/MIC among fluoroquinolones are clinically significant.

AB - The in vitro activity and pharmacodynamics (AUC0-24/MIC) of levofloxacin, gatifloxacin, moxifloxacin, and gemifloxacin were evaluated against 307 clinical isolates of Streptococcus pneumoniae from Indianapolis, Indiana. Organisms were collected between January 1999 and April 2000, and MICs were determined by broth microdilution. Serum concentration-time profiles were simulated for the following oral regimens administered once daily: levofloxacin 500 mg and 750 mg; gatifloxacin 400 mg; moxifloxacin 400 mg; gemifloxacin 320 mg. Free 24 h area under the serum concentration-time curves (AUC0-24) were calculated, and the average AUC0-24/MIC was calculated for each regimen. Differences in AUC0-24/MIC among agents were determined by analysis of variance (Scheffe post-hoc test, p < 0.05). Overall, gemifloxacin was the most potent agent tested. Five (1.7%), 4 (1.3%), and 2 (0.7%) isolates were resistant to levofloxacin, gatifloxacin, and moxifloxacin, respectively. None of the isolates was resistant to gemifloxacin. Gemifloxacin AUC0-24/MIC was significantly greater than all other regimens (p<0.0001), with the exception of moxifloxacin. However, the percent of isolates for which an AUC0-24/MIC ≥30-50 can be achieved is similar for gemifloxacin, moxifloxacin, gatifloxacin, and levofloxacin 750 mg. Large comparative studies are needed to determine if the differences in AUC0-24/MIC among fluoroquinolones are clinically significant.

UR - http://www.scopus.com/inward/record.url?scp=0034802578&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034802578&partnerID=8YFLogxK

U2 - 10.1016/S0732-8893(01)00277-2

DO - 10.1016/S0732-8893(01)00277-2

M3 - Article

C2 - 11576793

AN - SCOPUS:0034802578

VL - 40

SP - 193

EP - 198

JO - Diagnostic Microbiology and Infectious Disease

JF - Diagnostic Microbiology and Infectious Disease

SN - 0732-8893

IS - 4

ER -