Fluoxetine augmentation of clozapine treatment in patients with schizophrenia

Robert W. Buchanan, Brian Kirkpatrick, Nancy Bryant, Patricia Ball, Alan Breier

Research output: Contribution to journalArticle

100 Citations (Scopus)

Abstract

Objective: The authors examined the efficacy fluoxetine augmentation of clozapine treatment response in schizophrenic outpatient who, despite adequate treatment with clozapine, continued to exhibit persistent positive or negative symptoms. Method: Thirty-three patients completed an 8-week, double-blind, parallel-groups comparison of adjunctive fluoxetine and placebo. Results: There were no significant differences in positive, negative, depressive, or obsessive-compulsive symptoms between patients given adjunctive fluoxetine or placebo. Conclusions: These results suggest that fluoxetine is not effective in augmenting clozapine treatment response.

Original languageEnglish (US)
Pages (from-to)1625-1627
Number of pages3
JournalAmerican Journal of Psychiatry
Volume153
Issue number12
StatePublished - Dec 1996
Externally publishedYes

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Clozapine
Fluoxetine
Schizophrenia
Placebos
Therapeutics
Outpatients

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Buchanan, R. W., Kirkpatrick, B., Bryant, N., Ball, P., & Breier, A. (1996). Fluoxetine augmentation of clozapine treatment in patients with schizophrenia. American Journal of Psychiatry, 153(12), 1625-1627.

Fluoxetine augmentation of clozapine treatment in patients with schizophrenia. / Buchanan, Robert W.; Kirkpatrick, Brian; Bryant, Nancy; Ball, Patricia; Breier, Alan.

In: American Journal of Psychiatry, Vol. 153, No. 12, 12.1996, p. 1625-1627.

Research output: Contribution to journalArticle

Buchanan, RW, Kirkpatrick, B, Bryant, N, Ball, P & Breier, A 1996, 'Fluoxetine augmentation of clozapine treatment in patients with schizophrenia', American Journal of Psychiatry, vol. 153, no. 12, pp. 1625-1627.
Buchanan, Robert W. ; Kirkpatrick, Brian ; Bryant, Nancy ; Ball, Patricia ; Breier, Alan. / Fluoxetine augmentation of clozapine treatment in patients with schizophrenia. In: American Journal of Psychiatry. 1996 ; Vol. 153, No. 12. pp. 1625-1627.
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