Objective: The authors examined the efficacy fluoxetine augmentation of clozapine treatment response in schizophrenic outpatient who, despite adequate treatment with clozapine, continued to exhibit persistent positive or negative symptoms. Method: Thirty-three patients completed an 8-week, double-blind, parallel-groups comparison of adjunctive fluoxetine and placebo. Results: There were no significant differences in positive, negative, depressive, or obsessive-compulsive symptoms between patients given adjunctive fluoxetine or placebo. Conclusions: These results suggest that fluoxetine is not effective in augmenting clozapine treatment response.
ASJC Scopus subject areas
- Psychiatry and Mental health