Fluoxetine augmentation of clozapine treatment in patients with schizophrenia

Robert W. Buchanan, Brian Kirkpatrick, Nancy Bryant, Patricia Ball, Alan Breier

Research output: Contribution to journalArticle

104 Scopus citations


Objective: The authors examined the efficacy fluoxetine augmentation of clozapine treatment response in schizophrenic outpatient who, despite adequate treatment with clozapine, continued to exhibit persistent positive or negative symptoms. Method: Thirty-three patients completed an 8-week, double-blind, parallel-groups comparison of adjunctive fluoxetine and placebo. Results: There were no significant differences in positive, negative, depressive, or obsessive-compulsive symptoms between patients given adjunctive fluoxetine or placebo. Conclusions: These results suggest that fluoxetine is not effective in augmenting clozapine treatment response.

Original languageEnglish (US)
Pages (from-to)1625-1627
Number of pages3
JournalAmerican Journal of Psychiatry
Issue number12
StatePublished - Dec 1996
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health

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