Fluoxetine increases the extracellular levels of serotonin in the nucleus accumbens

X. M. Guan, W. J. McBride

Research output: Contribution to journalArticle

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Abstract

The effects of an IP injection of the monoamine uptake inhibitor fluoxetine on the extracellular concentration of serotonin (5-HT), dopamine (DA), 5-hydroxyindoleacetic acid (5-HIAA), 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) in the nucleus accumbens of awake and freely moving rats were examined using a push-pull perfusion technique. Baseline values of 5-HT, 5-HIAA, DA, DOPAC and HVA in the perfusates were approximately 0.07, 13, 0.8, 49 and 12 pmol/hr, respectively. The IP administration of 5 and 10 mg/kg fluoxetine dose-dependently elevated the amounts of 5-HT 3- and 13-fold, respectively, in the push-pull perfusate, with the maximum reached within one hour after drug administration. Moreover, 10 mg/kg fluoxetine also significantly decreased the levels of 5-HIAA in the perfusate as much as 50% within 2-3 hours. On the other hand, no significant effect of 5 or 10 mg/kg fluoxetine was observed on the contents of DA, DOPAC and HVA in the push-pull perfusates. The data indicate that fluoxetine, in accord with its role as a 5-HT uptake inhibitor, increases the physiologically active pool of 5-HT in the nucleus accumbens under in vivo conditions.

Original languageEnglish (US)
Pages (from-to)43-46
Number of pages4
JournalBrain Research Bulletin
Volume21
Issue number1
DOIs
StatePublished - Jul 1988

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Keywords

  • Extracellular levels of monoamine metabolites
  • Extracellular levels of serotonin
  • Fluoxetine
  • Nucleus accumbens
  • Push-pull perfusion

ASJC Scopus subject areas

  • Neuroscience(all)

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