Focal cooling suppresses spontaneous epileptiform activity without changing the cortical motor threshold

Kameel M. Karkar, Paul A. Garcia, Lisa M. Bateman, Matthew D. Smyth, Nicholas Barbaro, Mitchel Berger

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

Purpose: Focal cerebral cooling has been shown to reduce epileptiform activity in animals. There are, however, few reports of this phenomenon in humans. Methods: Electrocorticography was performed before resection of a right frontal tumor in a patient with partial seizures. Cold saline was applied to the interictal spike focus, and its effect on the epileptiform discharges was observed. Results: Application of cold saline to the spike focus resulted in a transient, complete cessation of spiking. This effect was reproduced with a second application of cold saline. The motor threshold for electrical stimulation remained unchanged during the application of saline. Conclusions: In this patient with tumor-related epilepsy, focal cooling of the cortex reproducibly abolished interictal epileptiform discharges without changing the motor threshold to electrical stimulation.

Original languageEnglish (US)
Pages (from-to)932-935
Number of pages4
JournalEpilepsia
Volume43
Issue number8
DOIs
StatePublished - 2002
Externally publishedYes

Fingerprint

Electric Stimulation
Partial Epilepsy
Neoplasms
Seizures
Electrocorticography

Keywords

  • Cerebral cooling
  • Epileptiform
  • Motor threshold

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Karkar, K. M., Garcia, P. A., Bateman, L. M., Smyth, M. D., Barbaro, N., & Berger, M. (2002). Focal cooling suppresses spontaneous epileptiform activity without changing the cortical motor threshold. Epilepsia, 43(8), 932-935. https://doi.org/10.1046/j.1528-1157.2002.03902.x

Focal cooling suppresses spontaneous epileptiform activity without changing the cortical motor threshold. / Karkar, Kameel M.; Garcia, Paul A.; Bateman, Lisa M.; Smyth, Matthew D.; Barbaro, Nicholas; Berger, Mitchel.

In: Epilepsia, Vol. 43, No. 8, 2002, p. 932-935.

Research output: Contribution to journalArticle

Karkar, KM, Garcia, PA, Bateman, LM, Smyth, MD, Barbaro, N & Berger, M 2002, 'Focal cooling suppresses spontaneous epileptiform activity without changing the cortical motor threshold', Epilepsia, vol. 43, no. 8, pp. 932-935. https://doi.org/10.1046/j.1528-1157.2002.03902.x
Karkar, Kameel M. ; Garcia, Paul A. ; Bateman, Lisa M. ; Smyth, Matthew D. ; Barbaro, Nicholas ; Berger, Mitchel. / Focal cooling suppresses spontaneous epileptiform activity without changing the cortical motor threshold. In: Epilepsia. 2002 ; Vol. 43, No. 8. pp. 932-935.
@article{b2df83c044bb44b38fe0c48258af665d,
title = "Focal cooling suppresses spontaneous epileptiform activity without changing the cortical motor threshold",
abstract = "Purpose: Focal cerebral cooling has been shown to reduce epileptiform activity in animals. There are, however, few reports of this phenomenon in humans. Methods: Electrocorticography was performed before resection of a right frontal tumor in a patient with partial seizures. Cold saline was applied to the interictal spike focus, and its effect on the epileptiform discharges was observed. Results: Application of cold saline to the spike focus resulted in a transient, complete cessation of spiking. This effect was reproduced with a second application of cold saline. The motor threshold for electrical stimulation remained unchanged during the application of saline. Conclusions: In this patient with tumor-related epilepsy, focal cooling of the cortex reproducibly abolished interictal epileptiform discharges without changing the motor threshold to electrical stimulation.",
keywords = "Cerebral cooling, Epileptiform, Motor threshold",
author = "Karkar, {Kameel M.} and Garcia, {Paul A.} and Bateman, {Lisa M.} and Smyth, {Matthew D.} and Nicholas Barbaro and Mitchel Berger",
year = "2002",
doi = "10.1046/j.1528-1157.2002.03902.x",
language = "English (US)",
volume = "43",
pages = "932--935",
journal = "Epilepsia",
issn = "0013-9580",
publisher = "Wiley-Blackwell",
number = "8",

}

TY - JOUR

T1 - Focal cooling suppresses spontaneous epileptiform activity without changing the cortical motor threshold

AU - Karkar, Kameel M.

AU - Garcia, Paul A.

AU - Bateman, Lisa M.

AU - Smyth, Matthew D.

AU - Barbaro, Nicholas

AU - Berger, Mitchel

PY - 2002

Y1 - 2002

N2 - Purpose: Focal cerebral cooling has been shown to reduce epileptiform activity in animals. There are, however, few reports of this phenomenon in humans. Methods: Electrocorticography was performed before resection of a right frontal tumor in a patient with partial seizures. Cold saline was applied to the interictal spike focus, and its effect on the epileptiform discharges was observed. Results: Application of cold saline to the spike focus resulted in a transient, complete cessation of spiking. This effect was reproduced with a second application of cold saline. The motor threshold for electrical stimulation remained unchanged during the application of saline. Conclusions: In this patient with tumor-related epilepsy, focal cooling of the cortex reproducibly abolished interictal epileptiform discharges without changing the motor threshold to electrical stimulation.

AB - Purpose: Focal cerebral cooling has been shown to reduce epileptiform activity in animals. There are, however, few reports of this phenomenon in humans. Methods: Electrocorticography was performed before resection of a right frontal tumor in a patient with partial seizures. Cold saline was applied to the interictal spike focus, and its effect on the epileptiform discharges was observed. Results: Application of cold saline to the spike focus resulted in a transient, complete cessation of spiking. This effect was reproduced with a second application of cold saline. The motor threshold for electrical stimulation remained unchanged during the application of saline. Conclusions: In this patient with tumor-related epilepsy, focal cooling of the cortex reproducibly abolished interictal epileptiform discharges without changing the motor threshold to electrical stimulation.

KW - Cerebral cooling

KW - Epileptiform

KW - Motor threshold

UR - http://www.scopus.com/inward/record.url?scp=0036340120&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036340120&partnerID=8YFLogxK

U2 - 10.1046/j.1528-1157.2002.03902.x

DO - 10.1046/j.1528-1157.2002.03902.x

M3 - Article

C2 - 12181015

AN - SCOPUS:0036340120

VL - 43

SP - 932

EP - 935

JO - Epilepsia

JF - Epilepsia

SN - 0013-9580

IS - 8

ER -