Focal cortical dysplasia: a review of pathological features, genetics, and surgical outcome.

Vincent Y. Wang, Edward F. Chang, Nicholas Barbaro

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Focal cortical dysplasia (FCD) is found in approximately one-half of patients with medically refractory epilepsy. These lesions may involve only mild disorganization of the cortex, but they may also contain abnormal neuronal elements such as balloon cells. Advances in neuroimaging have allowed better identification of these lesions, and thus more patients have become surgical candidates. Molecular biology techniques have been used to explore the genetics and pathophysiological characteristics of FCD. Data from surgical series have shown that surgery often results in significant reduction or cessation of seizures, especially if the entire lesion is resected.

Original languageEnglish (US)
JournalNeurosurgical Focus
Volume20
Issue number1
StatePublished - 2006
Externally publishedYes

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Malformations of Cortical Development
Neuroimaging
Molecular Biology
Epilepsy
Seizures

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Focal cortical dysplasia : a review of pathological features, genetics, and surgical outcome. / Wang, Vincent Y.; Chang, Edward F.; Barbaro, Nicholas.

In: Neurosurgical Focus, Vol. 20, No. 1, 2006.

Research output: Contribution to journalArticle

Wang, Vincent Y. ; Chang, Edward F. ; Barbaro, Nicholas. / Focal cortical dysplasia : a review of pathological features, genetics, and surgical outcome. In: Neurosurgical Focus. 2006 ; Vol. 20, No. 1.
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