Focal hepatic ablation using interstitial photon radiation energy

Leonidas Koniaris, David Y. Chan, Carolyn Magee, Stephen B. Solomon, James H. Anderson, Donald O. Smith, Theodore De Weese, Louis R. Kavoussi, Michael A. Choti

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Background: Intratumoral ablative therapy is being used increasingly for the treatment of primary and secondary hepatic malignancies. The interstitial point-source photon radiosurgery system (PRS) is a novel ablative technique that uses radiation therapy similar in dosimetry to interstitial brachytherapy. Study Design: To determine the feasibility, toxicity, and local tissue destructive capabilities of the PRS in the liver, preliminary studies in a nontumor-bearing canine model were examined. A 6-month survival study was conducted. Each animal received three radiation treatments, in the right, central, and left hepatic regions. Three low-dose treatments were delivered to each of six animals (group A), generating a 2.0-cm-diameter radiated sphere with a dose of 20 Gy at the lesion edge. Three high-dose treatments were delivered to each of six animals (group B), generating a 3.0-cm-diameter radiated sphere with 20 Gy at the lesion edge. Results: The treatment reproducibly generated sharply demarcated hepatic ablative lesions proportional to the administered dose. Mean lesion diameter at 1 month was 1.6 ± 0.2cm in group A and 3.4 ± 1.0cm in group B. Lesion size was independent of intrahepatic location, including near vascular structures. PRS therapy, when applied to portal structures, resulted in hilar damage. Hilar damage appeared to be associated with arteriolar thrombosis and bile duct injury. Treatment of regions adjacent to large hepatic veins and the IVC was not associated with vessel thrombosis or stricture. Conclusions: PRS ablation is a generally well-tolerated method that results in consistent, well-demarcated, symmetric lesions of complete necrosis with minimal adjacent parenchymal injury. Application of such an approach for the treatment of liver tumors is promising. (C) 2000 by the American College of Surgeons.

Original languageEnglish (US)
Pages (from-to)164-174
Number of pages11
JournalJournal of the American College of Surgeons
Volume191
Issue number2
DOIs
StatePublished - 2000
Externally publishedYes

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Photons
Radiation
Liver
Radiosurgery
Therapeutics
Thrombosis
Hepatic Veins
Brachytherapy
Wounds and Injuries
Bile Ducts
Blood Vessels
Canidae
Neoplasms
Pathologic Constriction
Necrosis
Radiotherapy

ASJC Scopus subject areas

  • Surgery

Cite this

Koniaris, L., Chan, D. Y., Magee, C., Solomon, S. B., Anderson, J. H., Smith, D. O., ... Choti, M. A. (2000). Focal hepatic ablation using interstitial photon radiation energy. Journal of the American College of Surgeons, 191(2), 164-174. https://doi.org/10.1016/S1072-7515(00)00295-7

Focal hepatic ablation using interstitial photon radiation energy. / Koniaris, Leonidas; Chan, David Y.; Magee, Carolyn; Solomon, Stephen B.; Anderson, James H.; Smith, Donald O.; De Weese, Theodore; Kavoussi, Louis R.; Choti, Michael A.

In: Journal of the American College of Surgeons, Vol. 191, No. 2, 2000, p. 164-174.

Research output: Contribution to journalArticle

Koniaris, L, Chan, DY, Magee, C, Solomon, SB, Anderson, JH, Smith, DO, De Weese, T, Kavoussi, LR & Choti, MA 2000, 'Focal hepatic ablation using interstitial photon radiation energy', Journal of the American College of Surgeons, vol. 191, no. 2, pp. 164-174. https://doi.org/10.1016/S1072-7515(00)00295-7
Koniaris, Leonidas ; Chan, David Y. ; Magee, Carolyn ; Solomon, Stephen B. ; Anderson, James H. ; Smith, Donald O. ; De Weese, Theodore ; Kavoussi, Louis R. ; Choti, Michael A. / Focal hepatic ablation using interstitial photon radiation energy. In: Journal of the American College of Surgeons. 2000 ; Vol. 191, No. 2. pp. 164-174.
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abstract = "Background: Intratumoral ablative therapy is being used increasingly for the treatment of primary and secondary hepatic malignancies. The interstitial point-source photon radiosurgery system (PRS) is a novel ablative technique that uses radiation therapy similar in dosimetry to interstitial brachytherapy. Study Design: To determine the feasibility, toxicity, and local tissue destructive capabilities of the PRS in the liver, preliminary studies in a nontumor-bearing canine model were examined. A 6-month survival study was conducted. Each animal received three radiation treatments, in the right, central, and left hepatic regions. Three low-dose treatments were delivered to each of six animals (group A), generating a 2.0-cm-diameter radiated sphere with a dose of 20 Gy at the lesion edge. Three high-dose treatments were delivered to each of six animals (group B), generating a 3.0-cm-diameter radiated sphere with 20 Gy at the lesion edge. Results: The treatment reproducibly generated sharply demarcated hepatic ablative lesions proportional to the administered dose. Mean lesion diameter at 1 month was 1.6 ± 0.2cm in group A and 3.4 ± 1.0cm in group B. Lesion size was independent of intrahepatic location, including near vascular structures. PRS therapy, when applied to portal structures, resulted in hilar damage. Hilar damage appeared to be associated with arteriolar thrombosis and bile duct injury. Treatment of regions adjacent to large hepatic veins and the IVC was not associated with vessel thrombosis or stricture. Conclusions: PRS ablation is a generally well-tolerated method that results in consistent, well-demarcated, symmetric lesions of complete necrosis with minimal adjacent parenchymal injury. Application of such an approach for the treatment of liver tumors is promising. (C) 2000 by the American College of Surgeons.",
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