Foci of Increased T2 Signal Intensity in MR Images of Healthy Elderly Subjects: A Follow‐Up Study

Hugh C. Hendrie, Richard F. Thompson, James Norton, Martin R. Farlow, Mary K. Edwards, Raymond Dean

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

An 18-month follow-up study was conducted on 26 healthy elderly subjects with and without foci of increased T2 signal intensity on MR imaging. The subjects did not differ with respect to health status or cognitive performance as measured by the Cognitive Subscale of the Cambridge Mental Disorders of the Elderly Examination and the Mini Mental State Examination at follow-up. There was a significant decline in performance on the Digit Symbol Substitution Test in subjects who had evidence of T2 foci compared to the performance of subjects without T2 foci. This may indicate that the presence of T2 foci is correlated with subtle difficulties in learning and memory.

Original languageEnglish (US)
Pages (from-to)1133-1138
Number of pages6
JournalJournal of the American Geriatrics Society
Volume38
Issue number10
DOIs
StatePublished - Oct 1990

ASJC Scopus subject areas

  • Geriatrics and Gerontology

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