Focused very high-energy electron beams as a novel radiotherapy modality for producing high-dose volumetric elements

K. Kokurewicz, E. Brunetti, G. H. Welsh, S. M. Wiggins, M. Boyd, A. Sorensen, A. J. Chalmers, G. Schettino, A. Subiel, Colleen DesRosiers, D. A. Jaroszynski

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The increased inertia of very high-energy electrons (VHEEs) due to relativistic effects reduces scattering and enables irradiation of deep-seated tumours. However, entrance and exit doses are high for collimated or diverging beams. Here, we perform a study based on Monte Carlo simulations of focused VHEE beams in a water phantom, showing that dose can be concentrated into a small, well-defined volumetric element, which can be shaped or scanned to treat deep-seated tumours. The dose to surrounding tissue is distributed over a larger volume, which reduces peak surface and exit doses for a single beam by more than one order of magnitude compared with a collimated beam.

Original languageEnglish (US)
Article number10837
JournalScientific reports
Volume9
Issue number1
DOIs
StatePublished - Dec 1 2019

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Radiotherapy
Electrons
Neoplasms
Water

ASJC Scopus subject areas

  • General

Cite this

Kokurewicz, K., Brunetti, E., Welsh, G. H., Wiggins, S. M., Boyd, M., Sorensen, A., ... Jaroszynski, D. A. (2019). Focused very high-energy electron beams as a novel radiotherapy modality for producing high-dose volumetric elements. Scientific reports, 9(1), [10837]. https://doi.org/10.1038/s41598-019-46630-w

Focused very high-energy electron beams as a novel radiotherapy modality for producing high-dose volumetric elements. / Kokurewicz, K.; Brunetti, E.; Welsh, G. H.; Wiggins, S. M.; Boyd, M.; Sorensen, A.; Chalmers, A. J.; Schettino, G.; Subiel, A.; DesRosiers, Colleen; Jaroszynski, D. A.

In: Scientific reports, Vol. 9, No. 1, 10837, 01.12.2019.

Research output: Contribution to journalArticle

Kokurewicz, K, Brunetti, E, Welsh, GH, Wiggins, SM, Boyd, M, Sorensen, A, Chalmers, AJ, Schettino, G, Subiel, A, DesRosiers, C & Jaroszynski, DA 2019, 'Focused very high-energy electron beams as a novel radiotherapy modality for producing high-dose volumetric elements', Scientific reports, vol. 9, no. 1, 10837. https://doi.org/10.1038/s41598-019-46630-w
Kokurewicz, K. ; Brunetti, E. ; Welsh, G. H. ; Wiggins, S. M. ; Boyd, M. ; Sorensen, A. ; Chalmers, A. J. ; Schettino, G. ; Subiel, A. ; DesRosiers, Colleen ; Jaroszynski, D. A. / Focused very high-energy electron beams as a novel radiotherapy modality for producing high-dose volumetric elements. In: Scientific reports. 2019 ; Vol. 9, No. 1.
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