Food-related odor probes of brain reward circuits during hunger: a pilot FMRI study.

Veronique Bragulat, Mario Dzemidzic, Carolina Bruno, Cari A. Cox, Thomas Talavage, Robert Considine, David Kareken

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

Food aromas can be powerful appetitive cues in the natural environment. Although several studies have examined the cerebral responses to food images, none have used naturalistic food aromas to study obesity. Ten individuals (five normal-weight and five obese) were recruited to undergo 24 h of food deprivation. Subjects were then imaged on a 3T Siemens Trio-Tim scanner (Siemens, Erlangen, Germany) while smelling four food-related odors (FRO; two sweet odors and two fat-related) and four "nonappetitive odors" (NApO; e.g., Douglas fir). Before the imaging session, subjects rated their desire to eat each type of food to determine their most preferred (P-FRO). Across all 10 subjects, P-FRO elicited a greater blood oxygenation level dependent (BOLD) response than the NApO in limbic and reward-related areas, including the bilateral insula and opercular (gustatory) cortex, the anterior and posterior cingulate, and ventral striatum. Obese subjects showed greater activation in the bilateral hippocampus/parahippocampal gyrus, but lean controls showed more activation in the posterior insula. Brain areas activated by food odors are similar to those elicited by cues of addictive substances, such as alcohol. Food odors are highly naturalistic stimuli, and may be effective probes of reward-related networks in the context of hunger and obesity.

Original languageEnglish (US)
Pages (from-to)1566-1571
Number of pages6
JournalObesity (Silver Spring, Md.)
Volume18
Issue number8
StatePublished - 2010
Externally publishedYes

Fingerprint

Hunger
Reward
Food
Brain
Gyrus Cinguli
Cues
Obesity
Pseudotsuga
Food Deprivation
Parahippocampal Gyrus
Odorants
Germany
Hippocampus
Fats
Alcohols
Weights and Measures

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics

Cite this

Food-related odor probes of brain reward circuits during hunger : a pilot FMRI study. / Bragulat, Veronique; Dzemidzic, Mario; Bruno, Carolina; Cox, Cari A.; Talavage, Thomas; Considine, Robert; Kareken, David.

In: Obesity (Silver Spring, Md.), Vol. 18, No. 8, 2010, p. 1566-1571.

Research output: Contribution to journalArticle

Bragulat, Veronique ; Dzemidzic, Mario ; Bruno, Carolina ; Cox, Cari A. ; Talavage, Thomas ; Considine, Robert ; Kareken, David. / Food-related odor probes of brain reward circuits during hunger : a pilot FMRI study. In: Obesity (Silver Spring, Md.). 2010 ; Vol. 18, No. 8. pp. 1566-1571.
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