Forced expiratory flows and volumes in infants: Normative data and lung growth

Marcus Jones, Robert Castile, Stephanie Davis, Jeff Kisling, Dave Filbrun, Robert Flucke, Amy Goldstein, Christine Emsley, Walter Ambrosius, Robert Tepper

Research output: Contribution to journalArticle

202 Citations (Scopus)

Abstract

Forced expiratory flows (FEF) can be measured in infants from lung volumes initiated near total lung capacity. In order to establish reference values and to evaluate lung growth, we obtained measurements in 155 healthy subjects between 3 and 149 wk of age. Forced vital capacity (FVC) was highly correlated with body length; however, after accounting for length, age was also significant. When subjects were divided at the median age (40 wk) younger compared with older subjects had a significantly larger slope for length (3.7 versus 2.8; p = 0.002). The flow parameters (FEF50, FEF75, FEF85, and FEF25-75) were highly correlated with length, and those infants whose mothers smoked had lower flows. For FEF75, male subjects had lower flows than female subjects. The relationship between FEF and volume was assessed using FEV0.5/FVC, which decreased with increasing length. Smaller subjects emptied their lung volume proportionately faster. We conclude that our study provides reference values for this age group and demonstrates that smoke-exposed infants and male subjects have decreased FEF. In addition, our findings indicate that lung volume increases most rapidly during the first year of life and that airways are large relative to lung volume very early in life.

Original languageEnglish
Pages (from-to)353-359
Number of pages7
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume161
Issue number2 I
StatePublished - 2000

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Forced Expiratory Volume
Lung
Growth
Vital Capacity
Reference Values
Total Lung Capacity
Smoke
Healthy Volunteers
Age Groups
Mothers

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Forced expiratory flows and volumes in infants : Normative data and lung growth. / Jones, Marcus; Castile, Robert; Davis, Stephanie; Kisling, Jeff; Filbrun, Dave; Flucke, Robert; Goldstein, Amy; Emsley, Christine; Ambrosius, Walter; Tepper, Robert.

In: American Journal of Respiratory and Critical Care Medicine, Vol. 161, No. 2 I, 2000, p. 353-359.

Research output: Contribution to journalArticle

Jones, M, Castile, R, Davis, S, Kisling, J, Filbrun, D, Flucke, R, Goldstein, A, Emsley, C, Ambrosius, W & Tepper, R 2000, 'Forced expiratory flows and volumes in infants: Normative data and lung growth', American Journal of Respiratory and Critical Care Medicine, vol. 161, no. 2 I, pp. 353-359.
Jones, Marcus ; Castile, Robert ; Davis, Stephanie ; Kisling, Jeff ; Filbrun, Dave ; Flucke, Robert ; Goldstein, Amy ; Emsley, Christine ; Ambrosius, Walter ; Tepper, Robert. / Forced expiratory flows and volumes in infants : Normative data and lung growth. In: American Journal of Respiratory and Critical Care Medicine. 2000 ; Vol. 161, No. 2 I. pp. 353-359.
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