Forced over-expression of the myeloid zinc finger gene MZF-1 inhibits apoptosis and promotes oncogenesis in interleukin-3-dependent FDCP.1 cells

R. Hromas, S. Boswell, R. N. Shen, G. Burgess, A. Davidson, K. Cornetta, J. Sutton, K. Robertson

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

The myeloid zinc finger protein MZF-1 is important in hematopoiesis. Previous studies have found that reducing expression of MZF-1 inhibited G-CSF-driven human marrow colony formation assays. In this study we found that retrovirally overexpressing MZF-1 in IL-3 dependent FDCP.1 cells inhibited their apoptosis when IL-3 was withdrawn. The MZF-1-transduced FDCP.1 cells also formed tumors when injected into congenic mice, whereas control FDCP.1 cells did not.

Original languageEnglish (US)
Pages (from-to)1049-1050
Number of pages2
JournalLeukemia
Volume10
Issue number6
StatePublished - Jun 1996

Keywords

  • Apoptosis
  • Oncogenesis
  • Retroviral gene transfer
  • Transcription factors

ASJC Scopus subject areas

  • Hematology
  • Cancer Research

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