Forced over-expression of the myeloid zinc finger gene MZF-1 inhibits apoptosis and promotes oncogenesis in interleukin-3-dependent FDCP.1 cells

R. Hromas, H. Boswell, R. N. Shen, G. Burgess, A. Davidson, Kenneth Cornetta, J. Sutton, Kent Robertson

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The myeloid zinc finger protein MZF-1 is important in hematopoiesis. Previous studies have found that reducing expression of MZF-1 inhibited G-CSF-driven human marrow colony formation assays. In this study we found that retrovirally overexpressing MZF-1 in IL-3 dependent FDCP.1 cells inhibited their apoptosis when IL-3 was withdrawn. The MZF-1-transduced FDCP.1 cells also formed tumors when injected into congenic mice, whereas control FDCP.1 cells did not.

Original languageEnglish
Pages (from-to)1049-1050
Number of pages2
JournalLeukemia
Volume10
Issue number6
StatePublished - Jun 1996

Fingerprint

Interleukin-3
Zinc Fingers
Carcinogenesis
Apoptosis
Genes
Congenic Mice
Hematopoiesis
Granulocyte Colony-Stimulating Factor
Bone Marrow
Neoplasms
Proteins

Keywords

  • Apoptosis
  • Oncogenesis
  • Retroviral gene transfer
  • Transcription factors

ASJC Scopus subject areas

  • Hematology
  • Cancer Research

Cite this

Forced over-expression of the myeloid zinc finger gene MZF-1 inhibits apoptosis and promotes oncogenesis in interleukin-3-dependent FDCP.1 cells. / Hromas, R.; Boswell, H.; Shen, R. N.; Burgess, G.; Davidson, A.; Cornetta, Kenneth; Sutton, J.; Robertson, Kent.

In: Leukemia, Vol. 10, No. 6, 06.1996, p. 1049-1050.

Research output: Contribution to journalArticle

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AU - Burgess, G.

AU - Davidson, A.

AU - Cornetta, Kenneth

AU - Sutton, J.

AU - Robertson, Kent

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