Four-vessel occlusion model in rats

Ping Deng, Zao C. Xu

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations


Four-vessel occlusion model in rat induces transient forebrain ischemia that resembles cardiac arrest in clinical situations. In this model, two vertebral arteries are coagulated and two common carotid arteries are revers-ibly occluded. This model produces reliable outcome with selective, delayed cell death. For example, CA1 pyramidal neurons in the hippocampus die 2-3 days after ischemia, whereas CA3 neurons survive the same insult. The complications of this model include mortality and seizure. The methods of quantitative analysis of ischemic outcome are introduced. The advantages and limitations of this model are discussed.

Original languageEnglish (US)
Title of host publicationAnimal Models of Acute Neurological Injuries
PublisherHumana Press
Number of pages12
ISBN (Print)9781603271844
StatePublished - Dec 1 2009


  • Hippocampus
  • Ischemic depolarization
  • Striatum
  • Transient global ischemia
  • Wistar rat

ASJC Scopus subject areas

  • Neuroscience(all)
  • Agricultural and Biological Sciences(all)

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    Deng, P., & Xu, Z. C. (2009). Four-vessel occlusion model in rats. In Animal Models of Acute Neurological Injuries (pp. 65-76). Humana Press.