FOXP3 interacts with hnRNPF to modulate pre-mRNA alternative splicing

Jianguang Du, Qun Wang, Steven F. Ziegler, Baohua Zhou

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

FOXP3 promotes the development and function of regulatory T cells mainly through regulating the transcription of target genes. RNA alternative splicing has been implicated in a wide range of physiological and pathophysiological processes. We report here that FOXP3 associates with heterogeneous nuclear ribonucleoprotein (hnRNP) F through the exon 2-encoded region of FOXP3 and the second quasi-RNA recognition motif (qRRM) of hnRNPF. FOXP3 represses the ability of hnRNPF to bind to its target pre-mRNA and thus modulates RNA alternative splicing. Furthermore, overexpression of mouse hnRNPF in in vitro-differentiated regulatory T cells (Tregs) reduced their suppressive function. Thus, our studies identify a novel mechanism by which FOXP3 regulates mRNA alternative splicing to modulate the function of regulatory T cells.

Original languageEnglish (US)
Pages (from-to)10235-10244
Number of pages10
JournalJournal of Biological Chemistry
Volume293
Issue number26
DOIs
StatePublished - Jun 29 2018

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'FOXP3 interacts with hnRNPF to modulate pre-mRNA alternative splicing'. Together they form a unique fingerprint.

  • Cite this