Fractionated laser resurfacing corrects the inappropriate UVB response in geriatric skin

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Non-melanoma skin cancer is a disease primarily afflicting geriatric patients as evidenced by the fact that 80% of all non-melanoma skin cancers are diagnosed in patients over the age of 60 years. As such, geriatric skin responds to cancer-inducing UVB irradiation in a manner that allows the establishment of tumor cells. Currently, the only effective treatment for non-melanoma skin cancer is the removal of the tumors after they appear, indicating the need for a more cost-effective prophylactic therapy. Geriatric volunteers were treated with fractionated laser resurfacing therapy on either sun-protected (upper buttocks) or chronically sun-exposed (dorsal forearm) skin. Fractionated laser resurfacing therapy was shown to decrease the occurrence of senescent fibroblasts in geriatric dermis, increase the dermal expression of IGF-1, and correct the inappropriate UVB response observed in untreated geriatric skin. These responses to fractionated laser resurfacing were equal to the effects seen previously using the more aggressive wounding following dermabrasion. Furthermore, fractionated laser resurfacing was equally effective in both sun-protected and sun-exposed skin. The ability of fractionated laser resurfacing treatment to protect against the occurrence of UVB-damaged proliferating keratinocytes indicates the potential of fractionated laser resurfacing to reduce or prevent aging-associated non-melanoma skin cancer.

Original languageEnglish
Pages (from-to)1591-1596
Number of pages6
JournalJournal of Investigative Dermatology
Volume132
Issue number6
DOIs
StatePublished - Jun 2012

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Geriatrics
Skin Neoplasms
Solar System
Skin
Lasers
Sun
Laser Therapy
Dermabrasion
Neoplasms
Buttocks
Tumors
Dermis
Insulin-Like Growth Factor I
Keratinocytes
Forearm
Volunteers
Therapeutics
Fibroblasts
Costs and Cost Analysis
Aging of materials

ASJC Scopus subject areas

  • Dermatology
  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

Fractionated laser resurfacing corrects the inappropriate UVB response in geriatric skin. / Spandau, Dan; Lewis, Davina A.; Somani, Ally-Khan; Travers, Jeffrey.

In: Journal of Investigative Dermatology, Vol. 132, No. 6, 06.2012, p. 1591-1596.

Research output: Contribution to journalArticle

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