Fragmented ECG as a risk marker in cardiovascular diseases

Rahul Jain, Robin Singh, Sundermurthy Yamini, Mithilesh Das

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Various noninvasive tests for risk stratification of sudden cardiac death (SCD) were studied, mostly in the context of structural heart disease such as coronary artery disease (CAD), cardiomyopathy and heart failure but have low positive predictive value for SCD. Fragmented QRS complexes (fQRS) on a 12-lead ECG is a marker of depolarization abnormality. fQRS include presence of various morphologies of the QRS wave with or without a Q wave and includes the presence of an additional R wave (R’) or notching in the nadir of the R’ (fragmentation) in two contiguous leads, corresponding to a major coronary artery territory. fQRS represents conduction delay from inhomogeneous activation of the ventricles due to myocardial scar. It has a high predictive value for myocardial scar and mortality in patients CAD. fQRS also predicts arrhythmic events and mortality in patients with implantable cardioverter defibrillator. It also signifies poor prognosis in patients with nonischemic cardiomyopathy, arrhythmogenic right ventricular cardiomyopathy and Brugada syndrome. However, fQRS is a nonspecific finding and its diagnostic prognostic should only be interpreted in the presence of pertinent clinical evidence and type of myocardial involvement (structural vs. structurally normal heart).

Original languageEnglish
Pages (from-to)277-286
Number of pages10
JournalCurrent Cardiology Reviews
Volume10
Issue number3
StatePublished - Jan 1 2014

Fingerprint

Electrocardiography
Cardiovascular Diseases
Sudden Cardiac Death
Cardiomyopathies
Cicatrix
Coronary Artery Disease
Arrhythmogenic Right Ventricular Dysplasia
Brugada Syndrome
Mortality
Implantable Defibrillators
Heart Diseases
Coronary Vessels
Heart Failure
Lead

Keywords

  • Cardiomyopathy
  • Coronary artery disease
  • Fragmented QRS

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Fragmented ECG as a risk marker in cardiovascular diseases. / Jain, Rahul; Singh, Robin; Yamini, Sundermurthy; Das, Mithilesh.

In: Current Cardiology Reviews, Vol. 10, No. 3, 01.01.2014, p. 277-286.

Research output: Contribution to journalArticle

Jain, R, Singh, R, Yamini, S & Das, M 2014, 'Fragmented ECG as a risk marker in cardiovascular diseases', Current Cardiology Reviews, vol. 10, no. 3, pp. 277-286.
Jain, Rahul ; Singh, Robin ; Yamini, Sundermurthy ; Das, Mithilesh. / Fragmented ECG as a risk marker in cardiovascular diseases. In: Current Cardiology Reviews. 2014 ; Vol. 10, No. 3. pp. 277-286.
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