Fragmented QRS complexes on 12-lead ECG: A marker of cardiac sarcoidosis as detected by gadolinium cardiac magnetic resonance imaging

Mohamed Homsi, Lamaan Alsayed, Bilal Safadi, Jo Mahenthiran, Mithilesh K. Das

Research output: Contribution to journalArticle

55 Scopus citations

Abstract

Background: Fragmented QRS complexes (fQRS) on a 12-lead ECG are a marker of myocardial scar in patients with coronary artery disease. Cardiac sarcoidosis is also associated with myocardial granuloma formation and scarring. We evaluated the significance of fQRS on a 12-lead ECG compared to Gadolinium-delayed enhancement images (GDE) in cardiac magnetic resonance imaging (CMR). Method and results: The ECGs of patients (n = 17, mean age: 52 ± 11 years, male: 53%) with established diagnosis of sarcoidosis who underwent a CMR for evaluation of cardiac involvement were studied. ECG abnormalities included bundle branch block, Q wave, and fQRS. fQRS, Q wave, and bundle branch block were present in 9 (53%), 1 (6%), and 4 (24%) patients, respectively. The sensitivity and specificity of fQRS for detecting abnormal GDE were 100% and 80%, respectively. Sensitivity and specificity of Q waves were 11% and 100%, respectively. Conclusions: fQRS on a 12-lead ECG in patients with suspected cardiac sarcoidosis are associated with cardiac involvement as detected by GDE on CMR.

Original languageEnglish (US)
Pages (from-to)319-326
Number of pages8
JournalAnnals of Noninvasive Electrocardiology
Volume14
Issue number4
DOIs
StatePublished - Nov 9 2009

Keywords

  • Cardiac sarcoidosis
  • Diagnosis
  • Electrocardiography
  • Gadolinium
  • Magnetic resonance
  • Sarcoidosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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