Free estradiol, free testosterone, and sex hormone-binding globulin in perimenopausal women

C. Longcope, Siu Hui, C. C. Johnston

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Abstract

To determine whether menstrual status had an effect on plasma sex hormone-binding globulin (SHBG) capacity and nonprotein-bound estradiol (% free E2) and testosterone (% free T), we measured these as well as plasma FSH, total E2, and T and the MCRs of E2 and T in a group of 78 perimenopausal women. The women were allocated to 4 groups: women with cycles whose plasma FSH level was less than 40 mIU/mL (A; n = 16), women with cycles whose plasma FSH level was greater than 40 mIU/mL (B; n = 19), women who were amenorrheic for less than 1 yr (C; n = 13), and women who were amenorrheic for more than 1 yr (D; n = 30). The mean plasma SHBG values were 51.4 ± 5.7 (±SE), 48.3 ± 4.3, 45.9 ± 5.4, and 51.1 ± 3.7 nM in groups 1-4 respectively, and were not significantly different from one another. The mean % free E2 and % free T values also were not different between the groups. However, the mean total E2 and free E2 (% free E2 x E2/100) concentrations were significantly (P <0.05) higher in both groups A and B than in groups C and D. The E2 concentration was also higher in group A than in group B. There were strong correlations between the E2 and free E2 concentrations between the T and free T (% free T x T/100); (P <0.0001) concentrations, between SHBG capacity and weight, and between the MCRs of both E2 and T and % free E2 and % free T. In normal women, the menopause is not associated with changes in SHBG or % free steroids. Hence, the measurement of E2 could be used to predict the mass of free E2 in these women.

Original languageEnglish (US)
Pages (from-to)513-518
Number of pages6
JournalJournal of Clinical Endocrinology and Metabolism
Volume64
Issue number3
StatePublished - 1987

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Sex Hormone-Binding Globulin
Testosterone
Estradiol
Plasmas
Steroids
Menopause
Weights and Measures

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Free estradiol, free testosterone, and sex hormone-binding globulin in perimenopausal women. / Longcope, C.; Hui, Siu; Johnston, C. C.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 64, No. 3, 1987, p. 513-518.

Research output: Contribution to journalArticle

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abstract = "To determine whether menstrual status had an effect on plasma sex hormone-binding globulin (SHBG) capacity and nonprotein-bound estradiol ({\%} free E2) and testosterone ({\%} free T), we measured these as well as plasma FSH, total E2, and T and the MCRs of E2 and T in a group of 78 perimenopausal women. The women were allocated to 4 groups: women with cycles whose plasma FSH level was less than 40 mIU/mL (A; n = 16), women with cycles whose plasma FSH level was greater than 40 mIU/mL (B; n = 19), women who were amenorrheic for less than 1 yr (C; n = 13), and women who were amenorrheic for more than 1 yr (D; n = 30). The mean plasma SHBG values were 51.4 ± 5.7 (±SE), 48.3 ± 4.3, 45.9 ± 5.4, and 51.1 ± 3.7 nM in groups 1-4 respectively, and were not significantly different from one another. The mean {\%} free E2 and {\%} free T values also were not different between the groups. However, the mean total E2 and free E2 ({\%} free E2 x E2/100) concentrations were significantly (P <0.05) higher in both groups A and B than in groups C and D. The E2 concentration was also higher in group A than in group B. There were strong correlations between the E2 and free E2 concentrations between the T and free T ({\%} free T x T/100); (P <0.0001) concentrations, between SHBG capacity and weight, and between the MCRs of both E2 and T and {\%} free E2 and {\%} free T. In normal women, the menopause is not associated with changes in SHBG or {\%} free steroids. Hence, the measurement of E2 could be used to predict the mass of free E2 in these women.",
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