Free estradiol, free testosterone, and sex hormone-binding globulin in perimenopausal women

C. Longcope, S. L. Hui, C. C. Johnston

Research output: Contribution to journalArticle

70 Scopus citations

Abstract

To determine whether menstrual status had an effect on plasma sex hormone-binding globulin (SHBG) capacity and nonprotein-bound estradiol (% free E2) and testosterone (% free T), we measured these as well as plasma FSH, total E2, and T and the MCRs of E2 and T in a group of 78 perimenopausal women. The women were allocated to 4 groups: women with cycles whose plasma FSH level was less than 40 mlU/mL (A; n = 16), women with cycles whose plasma FSH level was greater than 40 mlU/mL (B; n = 19), Women who were amenorrheic for less than 1 yr (C; n = 13), and women who were amenorrheic for more than 1 yr (D; n = 30).The mean plasma SHBG values were 51.4 ± 5.7 (±SE), 48.3 ± 4.3, 45.9 ± 5.4, and 51.1 ± 3.7 nM in groups 1 4 respectively, and were not significantly different from one another. The mean % free E2 and % free T values also were not different between the groups. However, the mean total E2 and free E2 (% free E2 A-E2/100) concentrations were significantly (P < 0.05) higher in both groups A and B than in groups C and D. The E2 concentration was also higher in group A than in group B. There were strong correlations between the E2 and free E2 concentrattions between the T and free T (% free T × T/100); (P < 0.0001) concentrations, between SHBG capacity and weight, and between the MCRs of both E2 and T and % free E2 and % free T.In normal women, the menopause is not associated with changes in SHBG or % free steroids. Hence, the measurement of E2 could be used to predict the mass of free E2 in these women.

Original languageEnglish (US)
Pages (from-to)513-518
Number of pages6
JournalJournal of Clinical Endocrinology and Metabolism
Volume64
Issue number3
DOIs
StatePublished - Mar 1987

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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