Free-radical-derived oxidants and ocular pathology in a model of chronic hypoxia

E. Ann Ellis, Gerard Holmes, Maria B. Grant

Research output: Contribution to conferencePaper

Abstract

Free radical derived oxidants have been implicated in the pathogenesis of vascular and other complications of hypoxia. Ocular pathology was more prominent in mature eyes than in immature eyes. Sites of retinal and optic nerve pathology were comparable at both time points. An additional site of ocular pathology is demyelination associated with perivascular localization of H2O2. The endothelial cell proliferation, reduplication of basement membranes, and demyelination demonstrate similar pathology to that observed in the retinopathy and peripheral neuropathy of diabetes.

Original languageEnglish (US)
Pages284-285
Number of pages2
StatePublished - Dec 1 1994
EventProceedings of the 52nd Annual Meeting of the Microscopy Society of America - New Orleans, LA, USA
Duration: Jul 31 1994Aug 5 1994

Other

OtherProceedings of the 52nd Annual Meeting of the Microscopy Society of America
CityNew Orleans, LA, USA
Period7/31/948/5/94

ASJC Scopus subject areas

  • Engineering(all)

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    Ellis, E. A., Holmes, G., & Grant, M. B. (1994). Free-radical-derived oxidants and ocular pathology in a model of chronic hypoxia. 284-285. Paper presented at Proceedings of the 52nd Annual Meeting of the Microscopy Society of America, New Orleans, LA, USA, .