Frequencies of sickle cell trait and glucose-6-phosphate dehydrogenase deficiency differ in highland and nearby lowland malaria-endemic areas of Kenya

A. M. Moormann, P. E. Embury, J. Opondo, O. P. Sumba, J. H. Ouma, J. W. Kazura, C. C. John

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Sickle cell genotype prevalence was 26% in a malaria-holoendemic lowland area compared with 3% in a highland area of Kenya. The prevalence of glucose-6-phosphate dehydrogenase deficiency was 7% and 1 % in holoendemic lowland and highland areas, respectively. Lack of protective polymorphisms may contribute to morbidity and mortality during outbreaks of malaria in the highlands.

Original languageEnglish (US)
Pages (from-to)513-514
Number of pages2
JournalTransactions of the Royal Society of Tropical Medicine and Hygiene
Volume97
Issue number5
DOIs
StatePublished - Sep 1 2003
Externally publishedYes

Keywords

  • Glucose-6-phosphate dehydrogenase
  • Kenya
  • Malaria
  • Plasmodium falciparum
  • Sickle cell trait

ASJC Scopus subject areas

  • Parasitology
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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