Frequency analysis of ventricular fibrillation in swine ventricles

Miguel Valderrábano, Junzhong Yang, Chikaya Omichi, John Kil, Scott T. Lamp, Zhilin Qu, Shien-Fong Lin, Hrayr S. Karagueuzian, Alan Garfinkel, Peng-Sheng Chen, James N. Weiss

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

It has been suggested from frequency analysis that cardiac fibrillation is driven by stable intramural reentry, with wavebreak occurring due to failure of 1:1 propagation. We tested this hypothesis with a combined experimental and theoretical approach. Optical mapping was performed on epicardial, endocardial, and transmural cut surfaces of fibrillating swine ventricles. Wavelets were characterized, the frequency content of optical signals analyzed, and space-time plots (STPs) constructed to detect Wenckebach-like conduction. The findings were compared with simulations in 2D and 3D cardiac tissue using the Luo-Rudy action potential model. The incidence of reentry in the cut transmural surface (11.8% in right ventricle, 14.3% in left ventricle) was similar to that on the endocardial surface (13.1%, P=NS) but greater than on the epicardial surface (7.7%, P

Original languageEnglish (US)
Pages (from-to)213-222
Number of pages10
JournalCirculation Research
Volume90
Issue number2
DOIs
StatePublished - Feb 8 2002
Externally publishedYes

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Ventricular Fibrillation
Heart Ventricles
Swine
Action Potentials
Incidence

Keywords

  • Fibrillation
  • Fourier transform
  • Reentry
  • Restitution

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Valderrábano, M., Yang, J., Omichi, C., Kil, J., Lamp, S. T., Qu, Z., ... Weiss, J. N. (2002). Frequency analysis of ventricular fibrillation in swine ventricles. Circulation Research, 90(2), 213-222. https://doi.org/10.1161/hh0202.103645

Frequency analysis of ventricular fibrillation in swine ventricles. / Valderrábano, Miguel; Yang, Junzhong; Omichi, Chikaya; Kil, John; Lamp, Scott T.; Qu, Zhilin; Lin, Shien-Fong; Karagueuzian, Hrayr S.; Garfinkel, Alan; Chen, Peng-Sheng; Weiss, James N.

In: Circulation Research, Vol. 90, No. 2, 08.02.2002, p. 213-222.

Research output: Contribution to journalArticle

Valderrábano, M, Yang, J, Omichi, C, Kil, J, Lamp, ST, Qu, Z, Lin, S-F, Karagueuzian, HS, Garfinkel, A, Chen, P-S & Weiss, JN 2002, 'Frequency analysis of ventricular fibrillation in swine ventricles', Circulation Research, vol. 90, no. 2, pp. 213-222. https://doi.org/10.1161/hh0202.103645
Valderrábano M, Yang J, Omichi C, Kil J, Lamp ST, Qu Z et al. Frequency analysis of ventricular fibrillation in swine ventricles. Circulation Research. 2002 Feb 8;90(2):213-222. https://doi.org/10.1161/hh0202.103645
Valderrábano, Miguel ; Yang, Junzhong ; Omichi, Chikaya ; Kil, John ; Lamp, Scott T. ; Qu, Zhilin ; Lin, Shien-Fong ; Karagueuzian, Hrayr S. ; Garfinkel, Alan ; Chen, Peng-Sheng ; Weiss, James N. / Frequency analysis of ventricular fibrillation in swine ventricles. In: Circulation Research. 2002 ; Vol. 90, No. 2. pp. 213-222.
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