Frequency and impact of lifestyle modification in patients with coronary artery disease: The Japanese Coronary Artery Disease (JCAD) Study

Takeki Suzuki, Takahide Kohro, Doubun Hayashi, Tsutomu Yamazaki, Ryozo Nagai

Research output: Contribution to journalArticle

Abstract

Background: Lifestyle modifications such as exercise and diet interventions in patients with coronary artery disease (CAD) are widely regarded as important, but little is known about their frequency in clinical practice and their impact on all-cause mortality. Methods: The JCAD study is a cohort study of 13,812 patients with CAD (≥75% stenosis in ≥1 of 3 major coronary arteries). Patients were enrolled from April 2000 through March 2001 at 202 institutions throughout Japan. Exercise and diet interventions were defined based on Japanese national guidelines. Cox proportional hazards models were used to calculate hazard ratios (HRs) for all-cause mortality with 95% CIs. Results: We studied 11,893 patients in the JCAD study. Over 3 years of follow-up, there were 474 deaths; 4,237 patients (35.6%) underwent exercise intervention, and 8,642 patients (72.7%) underwent diet intervention from the time of discharge. Mortality was lower in patients who underwent an exercise or diet intervention than in patients who did not: HR 0.68 (95% CI 0.56-0.84) and 0.75 (95% CI 0.62-0.91), respectively. After adjustment for age, sex, institution, hypertension, hyperlipidemia, diabetes, obesity, current drinking, current smoking, and the use of antiplatelet agents, β-blockers, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, and statins, the associations with these interventions remain statistically significant: HR 0.73 (95% CI 0.55-0.96) for exercise and 0.74 (95% CI 0.58-0.95) for diet interventions. Conclusions: Exercise and diet interventions have a beneficial impact on all-cause mortality in patients with CAD, yet these interventions are surprisingly infrequent. Lifestyle interventions should be more actively promoted.

Original languageEnglish (US)
Pages (from-to)268-273
Number of pages6
JournalAmerican Heart Journal
Volume163
Issue number2
DOIs
StatePublished - Feb 1 2012
Externally publishedYes

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Life Style
Coronary Artery Disease
Exercise
Diet
Mortality
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Angiotensin Receptor Antagonists
Platelet Aggregation Inhibitors
Hyperlipidemias
Proportional Hazards Models
Angiotensin-Converting Enzyme Inhibitors
Drinking
Coronary Vessels
Japan
Pathologic Constriction
Cohort Studies
Obesity
Smoking
Guidelines
Hypertension

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Frequency and impact of lifestyle modification in patients with coronary artery disease : The Japanese Coronary Artery Disease (JCAD) Study. / Suzuki, Takeki; Kohro, Takahide; Hayashi, Doubun; Yamazaki, Tsutomu; Nagai, Ryozo.

In: American Heart Journal, Vol. 163, No. 2, 01.02.2012, p. 268-273.

Research output: Contribution to journalArticle

Suzuki, Takeki ; Kohro, Takahide ; Hayashi, Doubun ; Yamazaki, Tsutomu ; Nagai, Ryozo. / Frequency and impact of lifestyle modification in patients with coronary artery disease : The Japanese Coronary Artery Disease (JCAD) Study. In: American Heart Journal. 2012 ; Vol. 163, No. 2. pp. 268-273.
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