Frequency and significance of antinuclear antibodies in multiple sclerosis

Robert C. Collard, Richard P M Koehler, David Mattson

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

In a prospective sample of patients with multiple sclerosis (MS) we found a high frequency of antinuclear antibodies (ANA), 22.5%, confirming results from previous studies. ANA occurrence did not correlate with gender, age, duration of MS, MS course, or disability in either the prospective and retrospective samples of MS patients. In 16 patients with MS tested at two time points, ANA occurrence did correlate with MS disease activity. This suggests that the high frequency of ANA in MS reflects ongoing immune dysregulation.

Original languageEnglish
Pages (from-to)857-861
Number of pages5
JournalNeurology
Volume49
Issue number3
StatePublished - Sep 1997

Fingerprint

Antinuclear Antibodies
Multiple Sclerosis

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Frequency and significance of antinuclear antibodies in multiple sclerosis. / Collard, Robert C.; Koehler, Richard P M; Mattson, David.

In: Neurology, Vol. 49, No. 3, 09.1997, p. 857-861.

Research output: Contribution to journalArticle

Collard, RC, Koehler, RPM & Mattson, D 1997, 'Frequency and significance of antinuclear antibodies in multiple sclerosis', Neurology, vol. 49, no. 3, pp. 857-861.
Collard, Robert C. ; Koehler, Richard P M ; Mattson, David. / Frequency and significance of antinuclear antibodies in multiple sclerosis. In: Neurology. 1997 ; Vol. 49, No. 3. pp. 857-861.
@article{04a7a2f4c799456ca8edd264fba1bd5a,
title = "Frequency and significance of antinuclear antibodies in multiple sclerosis",
abstract = "In a prospective sample of patients with multiple sclerosis (MS) we found a high frequency of antinuclear antibodies (ANA), 22.5{\%}, confirming results from previous studies. ANA occurrence did not correlate with gender, age, duration of MS, MS course, or disability in either the prospective and retrospective samples of MS patients. In 16 patients with MS tested at two time points, ANA occurrence did correlate with MS disease activity. This suggests that the high frequency of ANA in MS reflects ongoing immune dysregulation.",
author = "Collard, {Robert C.} and Koehler, {Richard P M} and David Mattson",
year = "1997",
month = "9",
language = "English",
volume = "49",
pages = "857--861",
journal = "Neurology",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Frequency and significance of antinuclear antibodies in multiple sclerosis

AU - Collard, Robert C.

AU - Koehler, Richard P M

AU - Mattson, David

PY - 1997/9

Y1 - 1997/9

N2 - In a prospective sample of patients with multiple sclerosis (MS) we found a high frequency of antinuclear antibodies (ANA), 22.5%, confirming results from previous studies. ANA occurrence did not correlate with gender, age, duration of MS, MS course, or disability in either the prospective and retrospective samples of MS patients. In 16 patients with MS tested at two time points, ANA occurrence did correlate with MS disease activity. This suggests that the high frequency of ANA in MS reflects ongoing immune dysregulation.

AB - In a prospective sample of patients with multiple sclerosis (MS) we found a high frequency of antinuclear antibodies (ANA), 22.5%, confirming results from previous studies. ANA occurrence did not correlate with gender, age, duration of MS, MS course, or disability in either the prospective and retrospective samples of MS patients. In 16 patients with MS tested at two time points, ANA occurrence did correlate with MS disease activity. This suggests that the high frequency of ANA in MS reflects ongoing immune dysregulation.

UR - http://www.scopus.com/inward/record.url?scp=0030882486&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030882486&partnerID=8YFLogxK

M3 - Article

VL - 49

SP - 857

EP - 861

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 3

ER -