Frequency and significance of antinuclear antibodies in multiple sclerosis

Robert C. Collard, Richard P.M. Koehler, David H. Mattson

Research output: Contribution to journalArticle

66 Scopus citations


In a prospective sample of patients with multiple sclerosis (MS) we found a high frequency of antinuclear antibodies (ANA), 22.5%, confirming results from previous studies. ANA occurrence did not correlate with gender, age, duration of MS, MS course, or disability in either the prospective and retrospective samples of MS patients. In 16 patients with MS tested at two time points, ANA occurrence did correlate with MS disease activity. This suggests that the high frequency of ANA in MS reflects ongoing immune dysregulation.

Original languageEnglish (US)
Pages (from-to)857-861
Number of pages5
Issue number3
StatePublished - Sep 1997

ASJC Scopus subject areas

  • Clinical Neurology

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