Frequency and volume thresholds for inhibition of inspiratory motor output during mechanical ventilation

Shalini Manchanda, A. M. Leevers, C. R. Wilson, P. M. Simon, J. B. Skatrud, J. A. Dempsey

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

We quantified volume and frequency thresholds necessary for the inhibition of respiratory motor output during prolonged normocapnic mechanical ventilation in healthy subjects during wakefulness (n = 7) and NREM sleep (n = 5). Subjects were ventilated at eupneic frequency (fR) with 3 min step-wise increases in tidal volume (VT), or at eupneic VT with step-wise increases in fR, or by combinations of these two parameters. Inhibition of respiratory motor output was determined using mask pressure and, when available, esophageal pressure and diaphragmatic EMG. During wakefulness, the volume threshold (at eupneic fR) averaged 969 ± 94 ml or 1.3-1.4 times the average eupneic tidal volume; the frequency threshold (at eupneic VT was 14.1 ± 0.7 min-1 or 1.2 times the average eupneic frequency. The volume threshold was reduced when MV was provided at an fR above the eupneic value, and the frequency threshold was decreased when MV was provided at a VT above the eupneic level. During NREM sleep (n = 5) the volume threshold for inhibition was 835 ± 108 ml or 1.4-1.5 times eupneic VT. The inhibitory thresholds for VT and fR were reproducible upon repeat trials within subjects. We conclude that inhibition of respiratory motor output during prolonged normocapnic mechanical ventilation in wakefulness or NREM sleep is highly sensitive to changes in ventilator VT, fR and their combination.

Original languageEnglish (US)
Pages (from-to)1-16
Number of pages16
JournalRespiration Physiology
Volume105
Issue number1-2
DOIs
StatePublished - Aug 1996
Externally publishedYes

Fingerprint

Artificial Respiration
Wakefulness
Sleep
Tidal Volume
Pressure
Mechanical Ventilators
Masks
Healthy Volunteers
Inhibition (Psychology)

Keywords

  • Control of breathing
  • Frequency, threshold
  • Mammals, humans
  • Motor output, respiratory
  • Threshold, motor output inhibition
  • Volume, threshold

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine

Cite this

Frequency and volume thresholds for inhibition of inspiratory motor output during mechanical ventilation. / Manchanda, Shalini; Leevers, A. M.; Wilson, C. R.; Simon, P. M.; Skatrud, J. B.; Dempsey, J. A.

In: Respiration Physiology, Vol. 105, No. 1-2, 08.1996, p. 1-16.

Research output: Contribution to journalArticle

Manchanda, Shalini ; Leevers, A. M. ; Wilson, C. R. ; Simon, P. M. ; Skatrud, J. B. ; Dempsey, J. A. / Frequency and volume thresholds for inhibition of inspiratory motor output during mechanical ventilation. In: Respiration Physiology. 1996 ; Vol. 105, No. 1-2. pp. 1-16.
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