Frequency of abnormal sphincter of Oddi manometry (SOM) in alcoholic pancreatitis

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Abstract

The mechanism(s) by which alcohol causes pancreatitis is unclear. A direct effect of alcohol on the pancreatic duct sphincter of Oddi may play a significant role. Our aim was to review the frequency of sphincter of Oddi dysfunction (SOD) in patients with alcoholic pancreatitis. Methods: Forty patients with a history of recurrent pancreatitis (history of ingestion of >50 gms ethanol per day >5 yrs) and recurrent pain underwent ERCP and SOM. All patients abstained from ethanol for at least 7 days before SOM. All patients underwent pancreatic (PD) manometry and 25 patients additionally had biliary (BD) manometry. SOM was performed using a triple-lumen water-perfused catheter with one lumen used for aspiration; pressures were measured by station pull-through. SOD was diagnosed when the mean basal pressure was ≥40 mmHg. Pancreatograms were evaluated for chronic pancreatitis based on the Cambridge criteria. Phasic waves were not evaluated. Results: ABNORMAL BASAL SPHINCTER PRESSURE BD & PD SOM PD SOM Pancreatogram Both PD alone BD alone PD alone Overall SOD frequency (%) Chronic (n=30) pancreatitis 8 3 1 11 23(76%) Normal (n=10) 3 2 2 2 9(90%) Associated findings included pseudocyst in 5, main pancreatic duct stricture in 10, and pancreatic stone disease in 2 patients. Summary: Abnormal basal SO pressure was present in 76% (23/30) of patients with ERCP evidence of chronic pancreatitis and 90% (9/10) with normal pancreatograms. Conclusions: Further studies are needed to determine the clinical significance (cause of chronic pancreatitis vs result) of the observed abnormal sphincter manometry.

Original languageEnglish (US)
Pages (from-to)AB111
JournalGastrointestinal endoscopy
Volume47
Issue number4
StatePublished - Dec 1 1998

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Gastroenterology

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