Frequency of abnormal sphincter of Oddi manometry (SOM) in alcoholic pancreatitis

Research output: Contribution to journalArticle

Abstract

The mechanism(s) by which alcohol causes pancreatitis is unclear. A direct effect of alcohol on the pancreatic duct sphincter of Oddi may play a significant role. Our aim was to review the frequency of sphincter of Oddi dysfunction (SOD) in patients with alcoholic pancreatitis. Methods: Forty patients with a history of recurrent pancreatitis (history of ingestion of >50 gms ethanol per day >5 yrs) and recurrent pain underwent ERCP and SOM. All patients abstained from ethanol for at least 7 days before SOM. All patients underwent pancreatic (PD) manometry and 25 patients additionally had biliary (BD) manometry. SOM was performed using a triple-lumen water-perfused catheter with one lumen used for aspiration; pressures were measured by station pull-through. SOD was diagnosed when the mean basal pressure was ≥40 mmHg. Pancreatograms were evaluated for chronic pancreatitis based on the Cambridge criteria. Phasic waves were not evaluated. Results: ABNORMAL BASAL SPHINCTER PRESSURE BD & PD SOM PD SOM Pancreatogram Both PD alone BD alone PD alone Overall SOD frequency (%) Chronic (n=30) pancreatitis 8 3 1 11 23(76%) Normal (n=10) 3 2 2 2 9(90%) Associated findings included pseudocyst in 5, main pancreatic duct stricture in 10, and pancreatic stone disease in 2 patients. Summary: Abnormal basal SO pressure was present in 76% (23/30) of patients with ERCP evidence of chronic pancreatitis and 90% (9/10) with normal pancreatograms. Conclusions: Further studies are needed to determine the clinical significance (cause of chronic pancreatitis vs result) of the observed abnormal sphincter manometry.

Original languageEnglish
JournalGastrointestinal Endoscopy
Volume47
Issue number4
StatePublished - 1998

Fingerprint

Alcoholic Pancreatitis
Sphincter of Oddi
Manometry
Sphincter of Oddi Dysfunction
Chronic Pancreatitis
Pancreatitis
Pressure
Endoscopic Retrograde Cholangiopancreatography
Pancreatic Ducts
Ethanol
Alcohols
Pancreatic Diseases
Pathologic Constriction
Catheters
Eating
Pain

ASJC Scopus subject areas

  • Gastroenterology

Cite this

@article{ebb4744db7674b5c82a0a3e2435e4018,
title = "Frequency of abnormal sphincter of Oddi manometry (SOM) in alcoholic pancreatitis",
abstract = "The mechanism(s) by which alcohol causes pancreatitis is unclear. A direct effect of alcohol on the pancreatic duct sphincter of Oddi may play a significant role. Our aim was to review the frequency of sphincter of Oddi dysfunction (SOD) in patients with alcoholic pancreatitis. Methods: Forty patients with a history of recurrent pancreatitis (history of ingestion of >50 gms ethanol per day >5 yrs) and recurrent pain underwent ERCP and SOM. All patients abstained from ethanol for at least 7 days before SOM. All patients underwent pancreatic (PD) manometry and 25 patients additionally had biliary (BD) manometry. SOM was performed using a triple-lumen water-perfused catheter with one lumen used for aspiration; pressures were measured by station pull-through. SOD was diagnosed when the mean basal pressure was ≥40 mmHg. Pancreatograms were evaluated for chronic pancreatitis based on the Cambridge criteria. Phasic waves were not evaluated. Results: ABNORMAL BASAL SPHINCTER PRESSURE BD & PD SOM PD SOM Pancreatogram Both PD alone BD alone PD alone Overall SOD frequency ({\%}) Chronic (n=30) pancreatitis 8 3 1 11 23(76{\%}) Normal (n=10) 3 2 2 2 9(90{\%}) Associated findings included pseudocyst in 5, main pancreatic duct stricture in 10, and pancreatic stone disease in 2 patients. Summary: Abnormal basal SO pressure was present in 76{\%} (23/30) of patients with ERCP evidence of chronic pancreatitis and 90{\%} (9/10) with normal pancreatograms. Conclusions: Further studies are needed to determine the clinical significance (cause of chronic pancreatitis vs result) of the observed abnormal sphincter manometry.",
author = "Choudari, {C. P.} and Evan Fogel and Stuart Sherman and Glen Lehman",
year = "1998",
language = "English",
volume = "47",
journal = "Gastrointestinal Endoscopy",
issn = "0016-5107",
publisher = "Mosby Inc.",
number = "4",

}

TY - JOUR

T1 - Frequency of abnormal sphincter of Oddi manometry (SOM) in alcoholic pancreatitis

AU - Choudari, C. P.

AU - Fogel, Evan

AU - Sherman, Stuart

AU - Lehman, Glen

PY - 1998

Y1 - 1998

N2 - The mechanism(s) by which alcohol causes pancreatitis is unclear. A direct effect of alcohol on the pancreatic duct sphincter of Oddi may play a significant role. Our aim was to review the frequency of sphincter of Oddi dysfunction (SOD) in patients with alcoholic pancreatitis. Methods: Forty patients with a history of recurrent pancreatitis (history of ingestion of >50 gms ethanol per day >5 yrs) and recurrent pain underwent ERCP and SOM. All patients abstained from ethanol for at least 7 days before SOM. All patients underwent pancreatic (PD) manometry and 25 patients additionally had biliary (BD) manometry. SOM was performed using a triple-lumen water-perfused catheter with one lumen used for aspiration; pressures were measured by station pull-through. SOD was diagnosed when the mean basal pressure was ≥40 mmHg. Pancreatograms were evaluated for chronic pancreatitis based on the Cambridge criteria. Phasic waves were not evaluated. Results: ABNORMAL BASAL SPHINCTER PRESSURE BD & PD SOM PD SOM Pancreatogram Both PD alone BD alone PD alone Overall SOD frequency (%) Chronic (n=30) pancreatitis 8 3 1 11 23(76%) Normal (n=10) 3 2 2 2 9(90%) Associated findings included pseudocyst in 5, main pancreatic duct stricture in 10, and pancreatic stone disease in 2 patients. Summary: Abnormal basal SO pressure was present in 76% (23/30) of patients with ERCP evidence of chronic pancreatitis and 90% (9/10) with normal pancreatograms. Conclusions: Further studies are needed to determine the clinical significance (cause of chronic pancreatitis vs result) of the observed abnormal sphincter manometry.

AB - The mechanism(s) by which alcohol causes pancreatitis is unclear. A direct effect of alcohol on the pancreatic duct sphincter of Oddi may play a significant role. Our aim was to review the frequency of sphincter of Oddi dysfunction (SOD) in patients with alcoholic pancreatitis. Methods: Forty patients with a history of recurrent pancreatitis (history of ingestion of >50 gms ethanol per day >5 yrs) and recurrent pain underwent ERCP and SOM. All patients abstained from ethanol for at least 7 days before SOM. All patients underwent pancreatic (PD) manometry and 25 patients additionally had biliary (BD) manometry. SOM was performed using a triple-lumen water-perfused catheter with one lumen used for aspiration; pressures were measured by station pull-through. SOD was diagnosed when the mean basal pressure was ≥40 mmHg. Pancreatograms were evaluated for chronic pancreatitis based on the Cambridge criteria. Phasic waves were not evaluated. Results: ABNORMAL BASAL SPHINCTER PRESSURE BD & PD SOM PD SOM Pancreatogram Both PD alone BD alone PD alone Overall SOD frequency (%) Chronic (n=30) pancreatitis 8 3 1 11 23(76%) Normal (n=10) 3 2 2 2 9(90%) Associated findings included pseudocyst in 5, main pancreatic duct stricture in 10, and pancreatic stone disease in 2 patients. Summary: Abnormal basal SO pressure was present in 76% (23/30) of patients with ERCP evidence of chronic pancreatitis and 90% (9/10) with normal pancreatograms. Conclusions: Further studies are needed to determine the clinical significance (cause of chronic pancreatitis vs result) of the observed abnormal sphincter manometry.

UR - http://www.scopus.com/inward/record.url?scp=33748963071&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33748963071&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:33748963071

VL - 47

JO - Gastrointestinal Endoscopy

JF - Gastrointestinal Endoscopy

SN - 0016-5107

IS - 4

ER -