From PTK-STAT signaling to caspase expression and apoptosis induction

X. Y. Fu

Research output: Contribution to journalReview article

30 Scopus citations

Abstract

The cell growth and survival can be regulated by cytokine-induced signals. Nevertheless, the molecular mechanisms of signal transduction from cytokine receptors to mediators of cell growth and apoptosis are not well characterized. STAT (signal transducer and activator of transcription) proteins can be activated by protein tyrosine kinases (PTK) in response to a variety of cytokines. We have shown that STAT activation induces expression of caspases which may cause cells undergo apoptosis. A hypothesis is proposed that PTK-STAT signaling pathways can regulate induction of apoptosis in response to cytokines and other extracellular signals.

Original languageEnglish (US)
Pages (from-to)1201-1208
Number of pages8
JournalCell Death and Differentiation
Volume6
Issue number12
DOIs
StatePublished - Dec 1999

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Keywords

  • Apoptosis induction
  • Caspase
  • Gene regulation
  • Protein tyrosine kinase
  • STAT

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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