Frontal occipital and frontal temporal horn ratios: Comparison and validation of head ultrasound-derived indexes with MRI and ventricular volumes in infantile ventriculomegaly

Rupa Radhakrishnan, Brandon Patrick Brown, Stephen F. Kralik, Danielle Bain, Scott Persohn, Paul Territo, Andrew Jea, Boaz Karmazyn

Research output: Contribution to journalArticle

Abstract

OBJECTIVE. The purpose of our study was to assess whether linear ventricular dimensions—specifically, the frontal occipital horn ratio (FOHR) and frontal temporal horn ratio (FTHR) obtained from ultrasound (US)—are reliable measures of ventriculomegaly in infants. Our hypothesis was that these US measures would show good correlation with linear ventricular indexes and ventricular volumes obtained from MRI. MATERIALS AND METHODS. We retrospectively identified 90 infants (age ≤ 6 months corrected gestational age) with ventriculomegaly from 2014 to 2017 who had a total of 100 sets of US and MRI studies performed in a 3-day period. FOHR and FTHR were independently measured on US and MRI by two pediatric radiologists and two pediatric neuroradiologists, respectively. Ventricular and brain volumes were segmented from the MR images, and the ventricle-to-intracranial volume ratio was calculated. MRI served as the reference standard. Intraclass correlation coefficients and Bland-Altman analyses were generated to evaluate interobserver and US-MRI concordance. We assessed correlation of the FOHR and FTHR with the ventricle-to-intracranial volume ratio. RESULTS. Bland-Altman plots of the FOHR and FTHR between US and MRI showed excellent concordance with a bias of 0.05 (95% CI, –0.04 to 0.14) and 0.03 (95% CI, –0.06 to 0.13), respectively. There was good-to-excellent interobserver concordance for FOHR and FTHR on head US or MRI (r = 0.86–0.96). There was good correlation between ventricle-to-intracranial volume ratios and US- and MRI-derived FOHRs and FTHRs (r = 0.79–0.87). CONCLUSION. FOHR and FTHR obtained from US in infants with ventriculomegaly have excellent interobserver concordance, are concordant with MRI-derived linear ratios, and correlate with MRI-derived ventricular volumes. Therefore, US-derived FOHR and FTHR are reliable indexes for clinical follow-up of infantile ventriculomegaly.

Original languageEnglish (US)
Pages (from-to)925-931
Number of pages7
JournalAmerican Journal of Roentgenology
Volume213
Issue number4
DOIs
StatePublished - Jan 1 2019

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Temporal Lobe
Head
Pediatrics
Gestational Age
Brain

Keywords

  • Hydrocephalus
  • Interobserver concordance
  • Posthemorrhagic hydrocephalus
  • Preterm brain imaging
  • Ventriculomegaly

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Frontal occipital and frontal temporal horn ratios : Comparison and validation of head ultrasound-derived indexes with MRI and ventricular volumes in infantile ventriculomegaly. / Radhakrishnan, Rupa; Brown, Brandon Patrick; Kralik, Stephen F.; Bain, Danielle; Persohn, Scott; Territo, Paul; Jea, Andrew; Karmazyn, Boaz.

In: American Journal of Roentgenology, Vol. 213, No. 4, 01.01.2019, p. 925-931.

Research output: Contribution to journalArticle

Radhakrishnan, Rupa ; Brown, Brandon Patrick ; Kralik, Stephen F. ; Bain, Danielle ; Persohn, Scott ; Territo, Paul ; Jea, Andrew ; Karmazyn, Boaz. / Frontal occipital and frontal temporal horn ratios : Comparison and validation of head ultrasound-derived indexes with MRI and ventricular volumes in infantile ventriculomegaly. In: American Journal of Roentgenology. 2019 ; Vol. 213, No. 4. pp. 925-931.
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abstract = "OBJECTIVE. The purpose of our study was to assess whether linear ventricular dimensions—specifically, the frontal occipital horn ratio (FOHR) and frontal temporal horn ratio (FTHR) obtained from ultrasound (US)—are reliable measures of ventriculomegaly in infants. Our hypothesis was that these US measures would show good correlation with linear ventricular indexes and ventricular volumes obtained from MRI. MATERIALS AND METHODS. We retrospectively identified 90 infants (age ≤ 6 months corrected gestational age) with ventriculomegaly from 2014 to 2017 who had a total of 100 sets of US and MRI studies performed in a 3-day period. FOHR and FTHR were independently measured on US and MRI by two pediatric radiologists and two pediatric neuroradiologists, respectively. Ventricular and brain volumes were segmented from the MR images, and the ventricle-to-intracranial volume ratio was calculated. MRI served as the reference standard. Intraclass correlation coefficients and Bland-Altman analyses were generated to evaluate interobserver and US-MRI concordance. We assessed correlation of the FOHR and FTHR with the ventricle-to-intracranial volume ratio. RESULTS. Bland-Altman plots of the FOHR and FTHR between US and MRI showed excellent concordance with a bias of 0.05 (95{\%} CI, –0.04 to 0.14) and 0.03 (95{\%} CI, –0.06 to 0.13), respectively. There was good-to-excellent interobserver concordance for FOHR and FTHR on head US or MRI (r = 0.86–0.96). There was good correlation between ventricle-to-intracranial volume ratios and US- and MRI-derived FOHRs and FTHRs (r = 0.79–0.87). CONCLUSION. FOHR and FTHR obtained from US in infants with ventriculomegaly have excellent interobserver concordance, are concordant with MRI-derived linear ratios, and correlate with MRI-derived ventricular volumes. Therefore, US-derived FOHR and FTHR are reliable indexes for clinical follow-up of infantile ventriculomegaly.",
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author = "Rupa Radhakrishnan and Brown, {Brandon Patrick} and Kralik, {Stephen F.} and Danielle Bain and Scott Persohn and Paul Territo and Andrew Jea and Boaz Karmazyn",
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T1 - Frontal occipital and frontal temporal horn ratios

T2 - Comparison and validation of head ultrasound-derived indexes with MRI and ventricular volumes in infantile ventriculomegaly

AU - Radhakrishnan, Rupa

AU - Brown, Brandon Patrick

AU - Kralik, Stephen F.

AU - Bain, Danielle

AU - Persohn, Scott

AU - Territo, Paul

AU - Jea, Andrew

AU - Karmazyn, Boaz

PY - 2019/1/1

Y1 - 2019/1/1

N2 - OBJECTIVE. The purpose of our study was to assess whether linear ventricular dimensions—specifically, the frontal occipital horn ratio (FOHR) and frontal temporal horn ratio (FTHR) obtained from ultrasound (US)—are reliable measures of ventriculomegaly in infants. Our hypothesis was that these US measures would show good correlation with linear ventricular indexes and ventricular volumes obtained from MRI. MATERIALS AND METHODS. We retrospectively identified 90 infants (age ≤ 6 months corrected gestational age) with ventriculomegaly from 2014 to 2017 who had a total of 100 sets of US and MRI studies performed in a 3-day period. FOHR and FTHR were independently measured on US and MRI by two pediatric radiologists and two pediatric neuroradiologists, respectively. Ventricular and brain volumes were segmented from the MR images, and the ventricle-to-intracranial volume ratio was calculated. MRI served as the reference standard. Intraclass correlation coefficients and Bland-Altman analyses were generated to evaluate interobserver and US-MRI concordance. We assessed correlation of the FOHR and FTHR with the ventricle-to-intracranial volume ratio. RESULTS. Bland-Altman plots of the FOHR and FTHR between US and MRI showed excellent concordance with a bias of 0.05 (95% CI, –0.04 to 0.14) and 0.03 (95% CI, –0.06 to 0.13), respectively. There was good-to-excellent interobserver concordance for FOHR and FTHR on head US or MRI (r = 0.86–0.96). There was good correlation between ventricle-to-intracranial volume ratios and US- and MRI-derived FOHRs and FTHRs (r = 0.79–0.87). CONCLUSION. FOHR and FTHR obtained from US in infants with ventriculomegaly have excellent interobserver concordance, are concordant with MRI-derived linear ratios, and correlate with MRI-derived ventricular volumes. Therefore, US-derived FOHR and FTHR are reliable indexes for clinical follow-up of infantile ventriculomegaly.

AB - OBJECTIVE. The purpose of our study was to assess whether linear ventricular dimensions—specifically, the frontal occipital horn ratio (FOHR) and frontal temporal horn ratio (FTHR) obtained from ultrasound (US)—are reliable measures of ventriculomegaly in infants. Our hypothesis was that these US measures would show good correlation with linear ventricular indexes and ventricular volumes obtained from MRI. MATERIALS AND METHODS. We retrospectively identified 90 infants (age ≤ 6 months corrected gestational age) with ventriculomegaly from 2014 to 2017 who had a total of 100 sets of US and MRI studies performed in a 3-day period. FOHR and FTHR were independently measured on US and MRI by two pediatric radiologists and two pediatric neuroradiologists, respectively. Ventricular and brain volumes were segmented from the MR images, and the ventricle-to-intracranial volume ratio was calculated. MRI served as the reference standard. Intraclass correlation coefficients and Bland-Altman analyses were generated to evaluate interobserver and US-MRI concordance. We assessed correlation of the FOHR and FTHR with the ventricle-to-intracranial volume ratio. RESULTS. Bland-Altman plots of the FOHR and FTHR between US and MRI showed excellent concordance with a bias of 0.05 (95% CI, –0.04 to 0.14) and 0.03 (95% CI, –0.06 to 0.13), respectively. There was good-to-excellent interobserver concordance for FOHR and FTHR on head US or MRI (r = 0.86–0.96). There was good correlation between ventricle-to-intracranial volume ratios and US- and MRI-derived FOHRs and FTHRs (r = 0.79–0.87). CONCLUSION. FOHR and FTHR obtained from US in infants with ventriculomegaly have excellent interobserver concordance, are concordant with MRI-derived linear ratios, and correlate with MRI-derived ventricular volumes. Therefore, US-derived FOHR and FTHR are reliable indexes for clinical follow-up of infantile ventriculomegaly.

KW - Hydrocephalus

KW - Interobserver concordance

KW - Posthemorrhagic hydrocephalus

KW - Preterm brain imaging

KW - Ventriculomegaly

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