Frontal P300 Decrements in Antisocial Personality Disorder

Lance O. Bauer, Sean O'Connor, Victor M. Hesselbrock

Research output: Contribution to journalArticle

120 Scopus citations


Event‐related potentials (ERPs) were recorded from 83, 21‐ to 25‐year‐old nonalcoholic men varying in alcoholism vulnerability due to the presence/absence of an alcoholic family history or a personal history of antisocial personality disorder. ERPs were elicited by a visual oddball task in which the target was presented more frequently than the nontarget, in order to elicit impulsive or perseverative responding. Analyses of N200 and P300 revealed no group differences in the nontarget response. However, analyses of the target response revealed a significantly smaller P300 in the antisocial personality (ASP)+ group compared with the ASP‐ group. The P300 decrement was limited to frontal electrode sites and is interpreted as indicating the presence of subtle anterior brain dysfunction among ASP+ subjects.

Original languageEnglish (US)
Pages (from-to)1300-1305
Number of pages6
JournalAlcoholism: Clinical and Experimental Research
Issue number6
StatePublished - Dec 1994


  • Antisocial Personality
  • Event‐Related Potentials
  • P300

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology
  • Psychiatry and Mental health

Fingerprint Dive into the research topics of 'Frontal P300 Decrements in Antisocial Personality Disorder'. Together they form a unique fingerprint.

Cite this