Fuchs' endothelial dystrophy and glaucoma

Blair Boehmer, Clark Springs

Research output: Chapter in Book/Report/Conference proceedingChapter


Fuchs' Endothelial Dystrophy (FED) is a common disorder of the cornea that causes slow progressive endothelial degeneration with subsequent corneal edema and loss of vision in late stages. It is characterized by a thickened Descemet's membrane (DM) from the aberrant deposition of wide-spaced collagen and the development of guttae, or posterior excrescences that represent projections of abnormal extracellular matrix between DM and endothelial cells. The bilateral, though asymmetric, condition often presents clinically between the fourth and seventh decades of life and is reported to have a female predominance as high as 3.5:1. Pedigree analysis reveals an autosomal dominant inheritance pattern with variable expressivity, although sporadic cases are also reported. While several hypotheses exist, the primary etiology of FED is unknown. Multiple studies have proposed an association between FED and glaucoma including primary open angle, angle closure, and other glaucomas. The relationships remain unclear.

Original languageEnglish (US)
Title of host publicationThe Glaucoma Book
Subtitle of host publicationA Practical, Evidence-Based Approach to Patient Care
PublisherSpringer New York
Number of pages3
ISBN (Print)9780387766997
StatePublished - Jan 1 2010

ASJC Scopus subject areas

  • Medicine(all)

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    Boehmer, B., & Springs, C. (2010). Fuchs' endothelial dystrophy and glaucoma. In The Glaucoma Book: A Practical, Evidence-Based Approach to Patient Care (pp. 557-559). Springer New York. https://doi.org/10.1007/978-0-387-76700-0_48