Fuchs' endothelial dystrophy and glaucoma

Blair Boehmer, Clark Springs

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Fuchs' Endothelial Dystrophy (FED) is a common disorder of the cornea that causes slow progressive endothelial degeneration with subsequent corneal edema and loss of vision in late stages. It is characterized by a thickened Descemet's membrane (DM) from the aberrant deposition of wide-spaced collagen and the development of guttae, or posterior excrescences that represent projections of abnormal extracellular matrix between DM and endothelial cells. The bilateral, though asymmetric, condition often presents clinically between the fourth and seventh decades of life and is reported to have a female predominance as high as 3.5:1. Pedigree analysis reveals an autosomal dominant inheritance pattern with variable expressivity, although sporadic cases are also reported. While several hypotheses exist, the primary etiology of FED is unknown. Multiple studies have proposed an association between FED and glaucoma including primary open angle, angle closure, and other glaucomas. The relationships remain unclear.

Original languageEnglish
Title of host publicationtThe Glaucoma Book: A Practical, Evidence-Based Approach to Patient Care
PublisherSpringer New York
Pages557-559
Number of pages3
ISBN (Print)9780387766997
DOIs
StatePublished - 2010

Fingerprint

Glaucoma
Descemet Membrane
Corneal Edema
Angle Closure Glaucoma
Inheritance Patterns
Pedigree
Cornea
Extracellular Matrix
Collagen
Endothelial Cells
Corneal Dystrophy, Fuchs Endothelial, 1
Primary Open Angle Glaucoma

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Boehmer, B., & Springs, C. (2010). Fuchs' endothelial dystrophy and glaucoma. In tThe Glaucoma Book: A Practical, Evidence-Based Approach to Patient Care (pp. 557-559). Springer New York. https://doi.org/10.1007/978-0-387-76700-0_48

Fuchs' endothelial dystrophy and glaucoma. / Boehmer, Blair; Springs, Clark.

tThe Glaucoma Book: A Practical, Evidence-Based Approach to Patient Care. Springer New York, 2010. p. 557-559.

Research output: Chapter in Book/Report/Conference proceedingChapter

Boehmer, B & Springs, C 2010, Fuchs' endothelial dystrophy and glaucoma. in tThe Glaucoma Book: A Practical, Evidence-Based Approach to Patient Care. Springer New York, pp. 557-559. https://doi.org/10.1007/978-0-387-76700-0_48
Boehmer B, Springs C. Fuchs' endothelial dystrophy and glaucoma. In tThe Glaucoma Book: A Practical, Evidence-Based Approach to Patient Care. Springer New York. 2010. p. 557-559 https://doi.org/10.1007/978-0-387-76700-0_48
Boehmer, Blair ; Springs, Clark. / Fuchs' endothelial dystrophy and glaucoma. tThe Glaucoma Book: A Practical, Evidence-Based Approach to Patient Care. Springer New York, 2010. pp. 557-559
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